Protein Information

General Information
MoonProt ID367
First appeared in release2.0
Name(s)NCOAT, nuclear cytoplasmic O-GlcNAcase and acetyltransferase, Protein O-GlcNAcase Gene: Mgea5
UniProt IDQ9EQQ9 (OGA_MOUSE)
GO termsGO:0006044 N-acetylglucosamine metabolic process GO:0006517 protein deglycosylation GO:0008152 metabolic process GO:0009100 glycoprotein metabolic process GO:0004563 beta-N-acetylhexosaminidase activity GO:0016787 hydrolase activity GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0005634 nucleus GO:0005737 cytoplasm GO:0005829 cytosol GO:0016020 membrane GO:0004402 histone acetyltransferase activity
Organisms for which functions have been demonstratedmouse
Sequence length916 amino acids
FASTA sequence>sp|Q9EQQ9|OGA_MOUSE Protein O-GlcNAcase OS=Mus musculus GN=Mgea5 PE=1 SV=2 MVQKESQAALEERESERNANPAAASGASLEQSVAPAPGEDNPSGAGAAAVVGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKTSVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPSVLTKEEEKKQPDEEPMDMVVEKQEEAEHKNDNQILTEIVEAKMAEELRPMDTDKESMAESKSPEMSMQEDCIPDVAPMQTDEQTQKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCALVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGFPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionO-GlcNase, which removes regulatory O-GlcNAc modifications on proteins
References for functionToleman,C., Paterson,A.J., Whisenhunt,T.R. and Kudlow,J.E. (2004) Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities. J. Biol. Chem., 279, 53665–53673. PMID: 15485860
E.C. number3.2.1.169
Location of functional site(s)binding site: 67, 98, 174, 219, 285, 313; active site: 175
Cellular location of functionnucleus, cytoplasm
Comments
Function 2
Function descriptionhistone acetyltransferase (HAT), add acetyl groups to histones
References for function15485860
E.C. number2.3.1.48
Location of functional site(s)
Cellular location of functionnucleus
Comments