Protein Information

General Information
MoonProt ID37
First appeared in release1.0
Name(s)Enolase 2-phospho-D-glycerate hydro-lyase 2-phosphoglycerate dehydratase Gene Name: eno
UniProt IDQ1JML5 (ENO_STRPC), Reviewed
GO termsGO:0006096 glycolysis GO:0000287 magnesium ion binding GO:0004634 phosphopyruvate hydratase activity GO:0016829 lyase activity GO:0046872 metal ion binding GO:0000015 phosphopyruvate hydratase complex GO:0005576 extracellular region GO:0005737 cytoplasm GO:0009986 cell surface GO:0005515 protein binding
Organisms for which functions have been demonstratedStreptococcus pyogenes
Sequence length435
FASTA sequence>gi|387934189|gb|EIK42302.1| enolase [Streptococcus pyogenes HKU QMH11M0907901] MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYLGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMITLDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYTYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMIMPVGAPTFKEGLRWGAEVFHALKKILKERGLVTAVGDEGGFAPKFEGTEDGVETILKAIEAAGYEAGENGIMIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQVDYLEELVNKYPIITIEDGMDENDWDGWKVLTERLGKRVQLVGDDFFVTNTEYLARGIKENAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNLKK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysis
References for functionAntikainen J, Kuparinen V, L?hteenm?ki K, Korhonen TK. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. FEMS Immunol Med Microbiol. 2007 Dec. PMID: 17892475
E.C. number4.2.1.11
Location of functional site(s)Active site:205,344 Binding site:164,319,292,395,155,344 Metal binding site:292,243,319
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds plasminogen
References for functionAntikainen J, Kuparinen V, L?hteenm?ki K, Korhonen TK. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. FEMS Immunol Med Microbiol. 2007 Dec. PMID: 17892475
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments