Protein Information

General Information
MoonProt ID375
First appeared in release2.0
Name(s)phosphoglycerate kinase 1, PGK, Cell migration-inducing gene 10 protein Primer recognition protein 2, PRP 2, Gene: PGK1
UniProt IDP00558 (PGK1_HUMAN)
GO termsGO:0006094 gluconeogenesis GO:0006096 glycolytic process GO:0016310 phosphorylation GO:0030855 epithelial cell differentiation GO:0061621 canonical glycolysis GO:0000166 nucleotide binding GO:0004618 phosphoglycerate kinase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0005737 cytoplasm GO:0005829 cytosol GO:0016020 membrane GO:0045121 membrane raft GO:0070062 extracellular exosome GO:0003723 RNA binding GO:0003729 mRNA binding
Organisms for which functions have been demonstratedHomo sapiens (human)
Sequence length417 amino acids
FASTA sequence>sp|P00558|PGK1_HUMAN Phosphoglycerate kinase 1 OS=Homo sapiens GN=PGK1 PE=1 SV=3 MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI
Structure Information
PDB ID2ZGV, 2XE6
Quaternary structure
Function 1
Function descriptionphosphoglycerate kinase, enzyme, reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate
References for functionMichelson, Alan M., Alexander F. Markham, and Stuart H. Orkin. "Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase." Proceedings of the National Academy of Sciences 80.2 (1983): 472-476.
E.C. number2.7.2.3
Location of functional site(s)binding site: 39, 123, 171, 220, 313, 344; nucleotide binding: 373-376
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds mRNA, regulates expression of urokinase receptor, "Overexpression in H157 lung squamous carcinoma cells reduced cell surface uPAR expression as well as uPAR-mediated cellular functions at the post-transcriptional level."
References for function14764427
E.C. number
Location of functional site(s)
Cellular location of function
CommentsIncreased expression of urokinase (uPA) or its receptor (uPAR) has been inversely correlated with prognosis in lung cancer