Protein Information

General Information
MoonProt ID376
First appeared in release2.0
Name(s)phosphoglycerate kinase, Gene: pgk
UniProt IDQ7WTU1 (PGK_SPICI)
GO termsGO:0006096 glycolytic process GO:0016310 phosphorylation GO:0000166 nucleotide binding GO:0004618 phosphoglycerate kinase activity GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0005737 cytoplasm GO:0005515 protein binding GO:0003779 actin binidng
Organisms for which functions have been demonstratedSpiroplasma citri, a plant bacterial pathogen transmitted by insects
Sequence length412 amino acids
FASTA sequence>sp|Q7WTU1|PGK_SPICI Phosphoglycerate kinase OS=Spiroplasma citri GN=pgk PE=3 SV=1 MTNKKELKDVQVKGKKVLVRVDFNVPMKDGQVTDDNRIIAALPTIKYLIAQEAKVILFSHLGKVKTADDLEKRDMAPVAKVLEQKLGQPVKFINAFEGKQLEEAINEMHNKEVILFQNTRFADIINSNGQISVDSEGKAAAKRESKNDSALGKYWASLGDVFVNDAFGTAHRAHASNVGIAENITESCLGFLVEKEVKMLSQCVDNPVKPFVAIIGGAKVSDKIGVIEHLLTKADKILIGGGMAYTFFAAQGHKIGNSLLEVDKVEIAKTFLAKGQGKIILPIDALEAPEFADVPAKVTTGFDIDDGYMGLDIGPKTIELFKKELADAKTVTWNGPMGVFEFKNYSIGTKAVCEAIAELKGAFTLIGGGDSAAAAIQLGYKDKFTHISTGGGASLEYMEGKPLPGIEAVQSK
Structure Information
PDB IDNone, closest homologues are around 57% amino acid sequence identity
Quaternary structure
Function 1
Function descriptionenzyme, phosphoglycerate kinase, in glycolysis, ATP + 3-phospho-D-glycerate -> ADP + 3-phospho-D-glyceroyl phosphate
References for functionBové, Joseph M., et al. "Spiroplasma citri, a plant pathogenic mollicute: relationships with its two hosts, the plant and the leafhopper vector." Annual review of phytopathology 41.1 (2003): 483-500.
E.C. number2.7.2.3
Location of functional site(s)binding site: 37, 120, 172, 223, 310, 341; nucleotide binding: 368-371
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinding to actin filament in insect vector (Circulifer haemotoceps, leafhopper) during invasion
References for functionLabroussaa, F., Arricau-Bouvery, N., Dubrana, M.P. and Saillard, C. (2010) Entry of Spiroplasma citri into Circulifer haematoceps cells involves interaction between Spiroplasma phosphoglycerate kinase and leafhopper actin. Appl. Environ. Microbiol. 76, 1879–1886. 10.1128/AEM.02384-09.
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments