Protein Information

General Information
MoonProt ID378
First appeared in release2.0
Name(s)pinin, Gene: PNN
UniProt IDQ9H307 (PININ_HUMAN)
GO termsGO:0000398 mRNA splicing, via spliceosome GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006397 mRNA processing GO:0007155 cell adhesion GO:0008380 RNA splicing GO:0003677 DNA binding GO:0005198 structural molecule activity GO:0044822 poly(A) RNA binding GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005681 spliceosomal complex GO:0005882 intermediate filament GO:0005886 plasma membrane GO:0005911 cell-cell junction GO:0016020 membrane GO:0016607 nuclear speck GO:0030054 cell junction GO:0030057 desmosome GO:0071013 catalytic step 2 spliceosome GO:0035145 exon-exon junction complex
Organisms for which functions have been demonstratedHomo sapiens (human)
Sequence length717 amino acids
FASTA sequence>sp|Q9H307|PININ_HUMAN Pinin OS=Homo sapiens GN=PNN PE=1 SV=4 MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGFSDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDPEDDDVKKPALQSSVVATSKERTRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEMVENVKHVIADQEVMETNRVESVEPSENEASKELEPEMEFEIEPDKECKSLSPGKENVSALDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQEQGHLLPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptiontranscriptional activator
References for functionAlpatov R., Munguba G.C., Caton P., Joo J.H., Shi Y., Shi Y., Hunt M.E., Sugrue S.P. Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. Mol. Cell. Biol. 24:10223-10235(2004) PMID: 15542832
E.C. number
Location of functional site(s)
Cellular location of functionnucleus
Comments
Function 2
Function descriptionbinds RNA, involved in splicing of pre-mRNAs
References for function12051732
E.C. number
Location of functional site(s)
Cellular location of function
Comments