Protein Information

General Information
MoonProt ID382
First appeared in release2.0
Name(s)pyruvate kinase 1, cell division cycle protein 19, Gene name: CDC19, PYK1
UniProt IDP00549 (KPYK1_YEAST)
GO termsGO:0006090 pyruvate metabolic process GO:0006096 glycolytic process GO:0008152 metabolic process GO:0016310 phosphorylation GO:0000166 nucleotide binding GO:0035173 histone kinase activity GO:0000287 magnesium ion binding GO:0003824 catalytic activity GO:0004743 pyruvate kinase activity GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0030955 potassium ion binding GO:0046872 metal ion binding GO:0005737 cytoplasm
Organisms for which functions have been demonstratedSaccharomyces cerevisiae
Sequence length500 amino acids
FASTA sequence>sp|P00549|KPYK1_YEAST Pyruvate kinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC19 PE=1 SV=2 MSRLERLTSLNVVAGSDLRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSEELYPGRPLAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKEDLRFGVKNGVHMVFASFIRTANDVLTIREVLGEQGKDVKIIVKIENQQGVNNFDEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDDMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQVSTV
Structure Information
PDB ID1A3W
Quaternary structure
Function 1
Function descriptionpyruvate kinase, ATP + pyruvate <=> ADP + phosphoenolpyruvate.
References for functionMcNally, Teresa, et al. "The yeast pyruvate kinase gene does not contain a string of non-preferred codons: revised nucleotide sequence." FEBS letters 247.2 (1989): 312-316.
E.C. number2.7.1.40
Location of functional site(s)binding site: 49, 240, 265, 266, 298, 337, 452, 459, 484; metal binding: 51, 53, 84, 85, 242, 266; site: 240
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionhistone kinase, phosphorylates H3T11, protein kinase, part of SESAME complex
References for function26527276
E.C. number
Location of functional site(s)
Cellular location of functionnucleus
Comments