Protein Information

General Information
MoonProt ID383
First appeared in release2.0
Name(s)pyruvate kinase isozyme type M2, PKM2, M2-PK, PKM, Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozymem Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58, Gene: PKM
UniProt IDP14618 (KPYM_HUMAN)
GO termsGO:0006096 glycolytic process GO:0008152 metabolic process GO:0012501 programmed cell death GO:0016310 phosphorylation GO:0061621 canonical glycolysis GO:0098609 cell-cell adhesion GO:0000166 nucleotide binding GO:0000287 magnesium ion binding GO:0003824 catalytic activity GO:0004743 pyruvate kinase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0023026 MHC class II protein complex binding GO:0030955 potassium ion binding GO:0044822 poly(A) RNA binding GO:0046872 metal ion binding GO:0098641 cadherin binding involved in cell-cell adhesion GO:0005634 nucleus GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005829 cytosol GO:0005886 plasma membrane GO:0005913 cell-cell adherens junction GO:0005929 cilium GO:0031012 extracellular matrix GO:0031982 vesicle GO:0043209 myelin sheath GO:0070062 extracellular exosome GO:1903561 extracellular vesicle GO:0006351 transcription, DNA-templated GO:0005515 protein binding
Organisms for which functions have been demonstratedHomo sapiens (human)
Sequence length531 amino acids
FASTA sequence>sp|P14618|KPYM_HUMAN Pyruvate kinase PKM OS=Homo sapiens GN=PKM PE=1 SV=4 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
Structure Information
PDB ID3GQY, 3SRD, 3U2Z, 4JPG, 4QGC, 4QG8, 4RPP, 3G2G, 4QG9, 1ZJH, 4FXF, 4B2D, 4WJ8, 4QG6, 3BJT, 1T5A, 4G1N, 3BJF, 4YJ5
Quaternary structure
Function 1
Function descriptionpyruvate kinase, enzyme, glycolysis, ATP + pyruvate <=> ADP + phosphoenolpyruvate
References for functionKenzaburo, Tani, et al. "Human M 2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma." Gene 73.2 (1988): 509-516.
E.C. number2.7.1.40
Location of functional site(s)binding site: 70, 73, 106, 120, 207, 270, 295, 296, 328, 464, 482, 489; metal binding: 75, 77, 113, 114, 272, 296; site: 270, 433; nucleotide binding: 75-78
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionregulates transcription, binds to Oct-4 protein
References for function18191611
E.C. number
Location of functional site(s)
Cellular location of functionnucleus
Comments