Protein Information

General Information
MoonProt ID385
First appeared in release2.0
Name(s)Leucyl aminopeptidase Gene: pepA
UniProt IDQ4A9M4
GO termsGO:0006508 proteolysis GO:0019538 protein metabolic process GO:0004177 aminopeptidase activity GO:0008233 peptidase activity GO:0008235 metalloexopeptidase activity GO:0016787 hydrolase activity GO:0030145 manganese ion binding GO:0046872 metal ion binding GO:0005622 intracellular GO:0005737 cytoplasm GO:0008201 heparin binding
Organisms for which functions have been demonstratedMycoplasma hyopneumoniae
Sequence length459 amino acids
FASTA sequence>tr|Q4A9M4|Q4A9M4_MYCHJ Leucyl aminopeptidase OS=Mycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110) GN=pepA PE=4 SV=2 MKNFSEIFIKYSNKFESNRITIEPAYSDSQIPMLIKEDLAITEYLGQKKAYINLGSRSKELTPNRFRKIAAKLGHYPRDMQINFDKFPNSFLRYLIEVIAFQRSDIFSLRADYAKNRAKNRDILVVSSYLDELKPIIDKYQIINNSVNYARYYQNMPPNMASSEFLASEIQKKMNLNPKLTVKVLGENEVRKLGMNLLLAVNRGSTYDAKLVVISYEGLPGSQYKTAFIGKGITFDSGGYNIKTGMYMNDMKIDMSGAIICAAAIDALSQFNPLANVVAVLPLTDNRLNGDANTPDAVWRSMNGKTVEINNTDAEGRLILADAITYAIRQEKASEIISIATLTGAIRIALGETFTGAFANEEKIWKNFNEASKEAGELIWRMPLHQDFAQNIRDSKVADLKNTDFSGKAGSSSAAMFLAEFVEDKPFIHLDIAATAFVKNTPTGVMVRSLVEYILAKQN
Structure Information
PDB ID
Quaternary structure
Function 1
Function description leucine aminopeptidase (LAP)
References for functionJarocki VM, Santos J, Tacchi JL, Raymond BB, Deutscher AT, Jenkins C, Padula MP, Djordjevic SP. MHJ_0461 is a multifunctional leucine aminopeptidase on the surface of Mycoplasma hyopneumoniae. Open Biol. 2015 Jan;5(1):140175. doi: 10.1098/rsob.140175. PMID: 25589579.
E.C. numberEC:3.4.11.1
Location of functional site(s)
Cellular location of functionCell surface of Mycoplasma hyopneumoniae (pg 4)
Comments
Function 2
Function descriptionbinds to heparin
References for functionJarocki VM, Santos J, Tacchi JL, Raymond BB, Deutscher AT, Jenkins C, Padula MP, Djordjevic SP. MHJ_0461 is a multifunctional leucine aminopeptidase on the surface of Mycoplasma hyopneumoniae. Open Biol. 2015 Jan;5(1):140175. doi: 10.1098/rsob.140175. PMID: 25589579.
E.C. number
Location of functional site(s)
Cellular location of functionCell surface of Mycoplasma hyopneumoniae
Comments
Third Function
Function descriptionMHJ_0461 binds to plasminogen that would allow its conversion to plasmin.
References for functionVeronica M. Jarocki, Jerran Santos, Jessica L. Tacchi, Benjamin B. A. Raymond, Ania T. Deutscher, Cheryl Jenkins, Matthew P. Padula, Steven P. Djordjevic Open Biol. 2015 5 140175; DOI: 10.1098/rsob.140175. Published 14 January 2015
E.C. number
Location of functional site(s)
Cellular location of functionCell surface of Mycoplasma hyopneumoniae
Comments