Protein Information

General Information
MoonProt ID39
First appeared in release1.0
Name(s)Enolase 2-phospho-D-glycerate hydro-lyase 2-phosphoglycerate dehydratase Gene Name: eno
UniProt IDQ8DTS9
GO termsGO:0006096 glycolysis GO:0000287 magnesium ion binding GO:0004634 phosphopyruvate hydratase activity GO:0016829 lyase activity GO:0046872 metal ion binding GO:0000015 phosphopyruvate hydratase complex GO:0005576 extracellular region GO:0005737 cytoplasm GO:0009986 cell surface GO:0005515 protein binding
Organisms for which functions have been demonstratedStreptococcus mutans
Sequence length432
FASTA sequence>sp|Q8DTS9|ENO_STRMU Enolase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) GN=eno PE=1 SV=1 MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYGGLGTQKAVDNVNNIIAEALIGYDVRDQQAIDKAMIALDGTPNKGKLGANAILGVSIAVARAAADFLEIPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMIVPAGAPTFKEALRWGAEIFHALKKILKERGLETAVGDEGGFAPKFDGTEDAVETIIKAIETAGYKPGEEVFLGFDCASSEFYDNGVYDYTKFEGEKGAKRSAAEQIDYIEELVNKYPIITIEDAMDENDWDGWKALTARLGDRVQLVGDDFFVTNTDYLARGIKEGAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADISVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysis
References for functionJones MN, Holt RG. Cloning and characterization of an alpha-enolase of the oral pathogen Streptococcus mutans that binds human plasminogen. Biochem Biophys Res Commun. 2007 Dec 28;364(4):924-9. Epub 2007 Oct 25. PMID: 17964283
E.C. number4.2.1.11
Location of functional site(s)Active site:205,341 Binding site:316,164,341,155,392,289 Metal binding site:289,242,316
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds plasminogen
References for functionJones MN, Holt RG. Cloning and characterization of an alpha-enolase of the oral pathogen Streptococcus mutans that binds human plasminogen. Biochem Biophys Res Commun. 2007 Dec 28;364(4):924-9. PMID: 17964283
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments