Protein Information

General Information
MoonProt ID394
First appeared in release2.0
Name(s)triosephosphate isomerase, TIM,, Gene: TPI1
UniProt IDP60174 (TPIS_HUMAN)
GO termsGO:0006006 glucose metabolic process GO:0006094 gluconeogenesis GO:0006096 glycolytic process GO:0006098 pentose-phosphate shunt GO:0007275 multicellular organism development GO:0008152 metabolic process GO:0019563 glycerol catabolic process GO:0019682 glyceraldehyde-3-phosphate metabolic process GO:0046166 glyceraldehyde-3-phosphate biosynthetic process GO:0061621 canonical glycolysis GO:0003824 catalytic activity GO:0004807 triose-phosphate isomerase activity GO:0005515 protein binding GO:0016853 isomerase activity GO:0031625 ubiquitin protein ligase binding GO:0005615 extracellular space GO:0005634 nucleus GO:0005829 cytosol GO:0070062 extracellular exosome
Organisms for which functions have been demonstratedHomo sapiens (human)
Sequence length286 amino acids
FASTA sequence>sp|P60174|TPIS_HUMAN Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=3 MAEDGEEAEFHFAALYISGQWPRLRADTDLQRLGSSAMAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ
Structure Information
PDB ID4POC, 1WYI, 1HTI, 4BR1
Quaternary structure
Function 1
Function descriptiontriosephosphate isomerase, D-glyceraldehyde 3-phosphate <-> dihydroxyacetone phosphate, in glycolysis and gluconeogenesis
References for functionMaquat, Lynne E., R. Chilcote, and Patricia M. Ryan. "Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man." Journal of Biological Chemistry 260.6 (1985): 3748-3753.
E.C. number5.3.1.1
Location of functional site(s)binding site: 49, 51; active site: 133, 203
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptioninteract with rhZP3 and rhZP4, interactions with zona pellucida proteins of egg
References for function23355646, 15236338
E.C. number
Location of functional site(s)
Cellular location of functionhead of sperm, sperm membrane
Comments