Protein Information

General Information
MoonProt ID399
First appeared in release2.0
Name(s)VPS36, Vacuolar protein-sorting-associated protein 36, ESCRT-II complex subunit VPS36 Gene: Vps36
UniProt IDQ9VU87 (VPS36_DROME)
GO termsGO:0006810 transport GO:0007224 smoothened signaling pathway GO:0008105 asymmetric protein localization GO:0008283 cell proliferation GO:0008593 regulation of Notch signaling pathway GO:0015031 protein transport GO:0019233 sensory perception of pain GO:0042981 regulation of apoptotic process GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0045450 bicoid mRNA localization GO:0051028 mRNA transport GO:0003723 RNA binding GO:0003730 mRNA 3'-UTR binding GO:0032266 phosphatidylinositol-3-phosphate binding GO:0043130 ubiquitin binding GO:0000814 ESCRT II complex GO:0005737 cytoplasm GO:0005768 endosome GO:0031902 late endosome membrane GO:0003729 mRNA binding GO:0003730 mRNA 3-UTR binding
Organisms for which functions have been demonstratedDrosophila melanogaster
Sequence length399 amino acids
FASTA sequence>sp|Q9VU87|VPS36_DROME Vacuolar protein-sorting-associated protein 36 OS=Drosophila melanogaster GN=Vps36 PE=2 SV=2 MNRFAYVEARLSPNESFVSRDNRVKIYDGDQKTDFEDGEVVLTTHRLFWGRPGEIARAAVTLCLPLSYVISVSEETTASNFFGRKTRIIMHLHPPTSDKGPGPLDTSRATHIKLSGKNGLSVEFHSALRETLNARVWEILLTSEIIINGVASSPTLEPANDRLARIQKRTGIGGIERHLEAKAKATDENIALAFQDLSVLMAMAKDMVGVSKTISSKIRKQKGEISDDETVRFKSYLMSLGIDDPVTRDNFTSNSAYFSSLARQICEMLLDPIEEQGGMMSLADVYCRVNRARGLELLSPEDLLHACEQLSGPIRLRSFPSGARVLQLESHDDALIAVDTLEKVEAAESLAVEELAKQLGISLLLAKERLLVAERLGKVCRDESVEGLRFYPNLLLGRD
Structure Information
PDB IDnone, but structures of human homologue available
Quaternary structure
Function 1
Function descriptioncomponent of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesicles
References for functionHerz, Hans-Martin, et al. "Common and distinct genetic properties of ESCRT-II components in Drosophila." PLoS One 4.1 (2009): e4165.
E.C. number
Location of functional site(s)
Cellular location of function
Comments
Function 2
Function descriptionbind bicoid mRNA to cause localization to anterior of egg, binding directly and specifically to stem-loop V of the bicoid 39 UTR
References for function17268469
E.C. number
Location of functional site(s)
Cellular location of functionegg
Comments