Protein Information

General Information
MoonProt ID40
First appeared in release1.0
Name(s)enolase Alpha-enolase 2-phospho-D-glycerate hydro-lyase C-myc promoter-binding protein Enolase 1 MBP-1 MPB-1 ENO1L1, MBPB1, MPB1 Non-neural enolase NNE Phosphopyruvate hydratase Plasminogen-binding protein Gene Name: ENO1
UniProt IDP06733 (ENOA_HUMAN), Reviewed
GO termsGO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0005975 carbohydrate metabolic process GO:0006006 glucose metabolic process GO:0006094 gluconeogenesis GO:0006096 glycolysis GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-dependent GO:0009615 response to virus GO:0030308 negative regulation of cell growth GO:0044281 small molecule metabolic process GO:0045892 negative regulation of transcription, DNA-dependent GO:0000287 magnesium ion binding GO:0003677 DNA binding GO:0003700 sequence-specific DNA binding transcription factor activity GO:0003714 transcription corepressor activity GO:0004634 phosphopyruvate hydratase activity GO:0005515 protein binding GO:0016829 lyase activity GO:0046872 metal ion binding GO:0000015 phosphopyruvate hydratase comple GO:0005634 nucleus GO:0005737 cytoplasm GO:0005829 cytosol GO:0005886 plasma membrane GO:0016020 membrane GO:0031430 M band GO:0070062 extracellular vesicular exosome x GO:0005515 protein binding
Organisms for which functions have been demonstratedHomo sapiens
Sequence length434
FASTA sequence>gi|1167843|emb|CAA34360.1| alpha-enolase [Homo sapiens] MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK
Structure Information
PDB ID1TE6 2AKM 2AKZ 3UJE 3UJR 3UJS 3UJF 3UCC 3UCD
Quaternary structure
Function 1
Function descriptionenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysis
References for functionenzyme activity was assayed: Miles, L. A., Dahlberg, C. M., Plescia, J., Felez, J., Kato, K. & Plow, E. F. (1991). Role of cell-surface lysines in plasmin(ogen)-binding to cells: identification of alpha-enolase as a candidate plasminogen receptor. Biochemistry. 1991 Feb 12;30(6):1682-91. PMID: 1847072
E.C. number4.2.1.11
Location of functional site(s)Active site:343,210 Binding site:158,318,167,293,394 Metal binding site:318,245,293,40
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionplasminogen binding
References for functionRedlitz A, Fowler BJ, Plow EF, Miles LA. The role of an enolase-related molecule in plasminogen binding to cells. Eur J Biochem. 1995 Jan 15;227(1-2):407-15. PMID: 7851415
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments