Protein Information

General Information
MoonProt ID42
First appeared in release1.0
Name(s)Enolase Alpha-enolase 2-phospho-D-glycerate hydro-lyase Enolase 1 Non-neural enolase NNE
UniProt IDP04764 (ENOA_RAT), Reviewed
GO termsGO:0006096 glycolysis GO:0000287 magnesium ion binding GO:0004634 phosphopyruvate hydratase activity GO:0016829 lyase activity GO:0042803 protein homodimerization activity GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity GO:0000015 phosphopyruvate hydratase complex GO:0005737 cytoplasm GO:0005886 plasma membrane GO:0016020 membrane GO:0043005 neuron projection GO:0097060 synaptic membrane GO:0005515 protein binding
Organisms for which functions have been demonstratedRattus norvegicus
Sequence length434
FASTA sequence>sp|P04764|ENOA_RAT Alpha-enolase OS=Rattus norvegicus GN=Eno1 PE=1 SV=4 MSILKIHAREIFDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDNDKTRFMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDQLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNPEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKSAIAKAGYTDQVVIGMDVAASEFYRAGKYDLDFKSPDDASRYITPDQLADLYKSFIKDYPVVSIEDPFDQDDWDAWQKFTATAGIQVVGDDLTVTNPKRIAKAAGEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysis
References for functionBender, Klaus, et al. "Biochemical markers in inbred strains of the rat (Rattus norvegicus)." Immunogenetics 19.3 (1984): 257-266.
E.C. number4.2.1.11
Location of functional site(s)Active site:343,210 Binding site:158,318,167,293,394 Metal binding site:318,245,293,40
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionplasminogen binding
References for functionNakijama, K., Hamanoue, M., Takemoto, N., Hattori, T., Kato, K. & Kohsaka, S. (1994). Plasminogen binds specifically to a alpha-enolase on rat neuronal plasma membrane. J Neurochem. 1994 Dec;63(6):2048-57. PMID: 7964722
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments