Protein Information

General Information
MoonProt ID56
First appeared in release1.0
Name(s)GAPDH Glyceraldehyde-3-phosphate dehydrogenase Gene Name: gap
UniProt IDQ6GIL8
GO termsGO:0006006 glucose metabolic process GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0050661 NADP binding GO:0051287 NAD binding GO:0005515 protein binding GO:0006879 cellular iron ion homeostasis
Organisms for which functions have been demonstratedStaphylococcus aureus (S. epidermidis and S. aureus)
Sequence length336 aa
FASTA sequence>sp|Q6GIL8|G3P1_STAAR Glyceraldehyde-3-phosphate dehydrogenase 1 OS=Staphylococcus aureus (strain MRSA252) GN=gapA1 PE=1 SV=1 MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
Structure Information
PDB ID3LVF 3VAZ 3LC7 3K73 3L6O 3LC2 3LC1 3HQ4 3KV3 3K9Q 3L4S 3KSD 3KSZ
Quaternary structure
Function 1
Function descriptionGAPDH, glyceraldehyde 3-phosphate dehydrogenase, enzyme
References for functionModun, B., and Williams, P. (1999) The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3- phosphate dehydrogenase. Infect Immun. 1999 Mar;67(3):1086-92. PMID: 10024547
E.C. number1.2.1.12
Location of functional site(s)Active site:151 Binding site:181,316,198,120,234,34 Nucleotide binding site:12-13 Other functional site:178
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptiontransferrin-binding protein (also called TPN) AND also binds plasminogen involved in the acquisition of transferrin-bound iron
References for functionModun, B., and Williams, P. (1999) The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3- phosphate dehydrogenase. Infect Immun. 1999 Mar;67(3):1086-92. PMID: 10024547
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments