Protein Information

General Information
MoonProt ID58
First appeared in release1.0
Name(s)GAPDH glyceraldehyde 3-phosphate dehydrogenase TDH3 GAP, TDH3 Gene Name: TDH1
UniProt IDQ92211 (G3P_CANAW), Reviewed
GO termsGO:0006006 glucose metabolic process GO:0006096 glycolysis GO:0055114 oxidation-reduction process GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0050661 NADP binding GO:0051287 NAD binding GO:0005576 extracellular region GO:0005618 cell wall GO:0005737 cytoplasm GO:0098631 cell adhesion mediator GO:0005515 protein binding
Organisms for which functions have been demonstratedCandida albicans
Sequence length335
FASTA sequence>sp|Q92211|G3P_CANAW Glyceraldehyde-3-phosphate dehydrogenase OS=Candida albicans (strain WO-1) GN=TDH1 PE=1 SV=2 MAIKIGINGFGRIGRLVLRVALGRKDIEVVAVNDPFIAPDYAAYMFKYDSTHGRYKGEVTASGDDLVIDGHKIKVFQERDPANIPWGKSGVDYVIESTGVFTKLEGAQKHIDAGAKKVIITAPSADAPMFVVGVNEDKYTPDLKIISNASCTTNCLAPLAKVVNDTFGIEEGLMTTVHSITATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVIPELNGKLTGMSLRVPTTDVSVVDLTVRLKKAASYEEIAQAIKKASEGPLKGVLGYTEDAVVSTDFLGSSYSSIFDEKAGILLSPTFVKLISWYDNEYGYSTRVVDLLEHVAKASA
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionglyceraldehyde 3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphosphoglycerate + NADH. Carbohydrate degradation, glycolysis
References for functiondemonstrated enzyme activity: Gozalbo D, Gil-Navarro I, Azorin I, Renau-Piqueras J, Martinez JP, Gil ML: The cell wall-associated glyceraldehyde-3-phosphate dehydrogenase of Candida albicans is also a fibronectin and laminin binding protein. Infect Immun 1998, 66(5):2052-2059. PMID: 9573088
E.C. number1.2.1.12
Location of functional site(s)Active site:151 Binding site:233,181,79,34,315 Nucleotide binding site:12-13 Other functional site:178
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionplasminogen binding fibronectin and laminin binding
References for functionCrowe, J.D. et al. (2003) Candida albicans binds human plasminogen: identification of eight plasminogen-binding proteins. Mol. Microbiol. 47, 16371651. PMID: 12622818. Gozalbo D, Gil-Navarro I, Azorin I, Renau-Piqueras J, Martinez JP, Gil ML: The cell wall-associated glyceraldehyde-3-phosphate dehydrogenase of Candida albicans is also a fibronectin and laminin binding protein. Infect Immun 1998, 66(5):2052-2059. PMID: 9573088
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments