Protein Information

General Information
MoonProt ID61
First appeared in release1.0
Name(s)GAPDH glyceraldehyde 3-phosphate dehydrogenase gap Gene Name: gapA
UniProt IDP47543 (G3P_MYCGE), Reviewed
GO termsGO:0006006 glucose metabolic process GO:0006096 glycolysis GO:0055114 oxidation-reduction process GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0050661 NADP binding GO:0051287 NAD binding GO:0005737 cytoplasm GO:0005515 protein binding
Organisms for which functions have been demonstratedMycoplasma genitalium
Sequence length337
FASTA sequence>sp|P47543|G3P_MYCGE Glyceraldehyde-3-phosphate dehydrogenase OS=Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) GN=gapA PE=3 SV=1 MAAKNRTIKVAINGFGRIGRLVFRSLLSKANVEVVAINDLTQPEVLAHLLKYDSAHGELKRKITVKQNILQIDRKKVYVFSEKDPQNLPWDEHDIDVVIESTGRFVSEEGASLHLKAGAKRVIISAPAKEKTIRTVVYNVNHKTISSDDKIISAASCTTNCLAPLVHVLEKNFGIVYGTMLTVHAYTADQRLQDAPHNDLRRARAAAVNIVPTTTGAAKAIGLVVPEANGKLNGMSLRVPVLTGSIVELSVVLEKSPSVEQVNQAMKRFASASFKYCEDPIVSSDVVSSEYGSIFDSKLTNIVEVDGMKLYKVYAWYDNESSYVHQLVRVVSYCAKL
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionglyceraldehyde 3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphosphoglycerate + NADH Carbohydrate degradation, glycolysis
References for functiondemonstrated enzyme activity: Alvarez RA, Blaylock MW, Baseman JB: Surface localized glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma genitalium binds mucin. Mol Microbiol 2003, 48(5):1417-1425.
E.C. number1.2.1.12
Location of functional site(s)Active site:157 Binding site:125,202,319,39,83,238,187 Nucleotide binding site:17-18 Other functional site:184
Cellular location of function
Comments
Function 2
Function descriptionbinds mucin
References for functionAlvarez RA, Blaylock MW, Baseman JB: Surface localized glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma genitalium binds mucin. Mol Microbiol. 2003 Jun;48(5):1417-25. PMID: 12787366
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments