Protein Information

General Information
MoonProt ID68
First appeared in release1.0
Name(s)Hsp60 GroEL1 heat shock protein 60 (not GroEL2 or GroEL3) 60 kDa chaperonin GroEL protein Protein Cpn60 Gene Name: groL
UniProt IDP31681 (CH60_CHLPN), Reviewed
GO termsGO:0006457 protein folding GO:0006950 response to stress GO:0042026 protein refolding GO:0044267 cellular protein metabolic process GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0051082 unfolded protein binding GO:0005737 cytoplasm GO:0005515 protein binding
Organisms for which functions have been demonstratedChlamydiae pneumoniae
Sequence length544
FASTA sequence>gi|33235978|gb|AAP98068.1| GroEL [Chlamydophila pneumoniae TW-183] MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionchaperonin, assist in the correct folding of new or unfolded proteins under both normal and stress conditions
References for functionTakeda, Kiyoshi, Tsuneyasu Kaisho, and Shizuo Akira. "Toll-like receptors." Annual review of immunology 21.1 (2003): 335-376.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinding to cell surface and activates pathways
References for functionWuppermann FN, M?lleken K, Julien M, Jantos CA, Hegemann JH. Chlamydia pneumoniae GroEL1 protein is cell surface associated and required for infection of HEp-2 cells. J Bacteriol. 2008 May;190(10):3757-67. doi: 10.1128/JB.01638-07. Epub 2008 Feb 29. PMID: 18310329
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments