Protein Information

General Information
MoonProt ID69
First appeared in release1.0
Name(s)Hsp60 Heat shock protein 60, mitochondrial Antigen HIS-62 Gene Name: HSP60
UniProt IDP50142 (HSP60_AJECA), Reviewed
GO termsGO:0006457 protein folding GO:0006950 response to stress GO:0042026 protein refolding GO:0044267 cellular protein metabolic process GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005515 protein binding GO:0098631 cell adhesion mediator
Organisms for which functions have been demonstratedHistoplasma capsulatum (Hc strain G217B) - also known as Ajellomyces capsulatus
Sequence length590
FASTA sequence>gi|4558517|gb|AAB46362.2| heat shock protein 60 [Ajellomyces capsulatus] MQRALSSTSRASVLSSAPTRAPVSRFRSAGLSLQQQRFAHKELKFGVEGRAALLKGIDTLAKAVCTTLGPKGRNVLIESSYGSPKITKDGVTVAKAVTLQDKFENLGARLLQDVASKTNEVAGDGTTTATVLARAIFSETVKNVAAGCNPMDLRRGIQAAVEAVVEYLQANKRDITTTEEIAQVATISANGDTHVGKLISNAMEKVGKEGVITVKDGKTIEDELEVTEGMRFDRGYVSPYFITDTKAQKVEFEKPLIVLSEKKISAVQDIIPALEASTTLRRPLVIIAEDIEGEALAVCILNKLRGQLQVAAVKVPGFGDNRKSILGDIGILTNATVFTDELDMKLEKATADMLGSTGSITITKEDTIILNGDGSKDSIAQRCEQIRGVIADPTTSDYEKEKLQERLAKLSGGVAVIKVGGASEVEVGEKKDRVVDALNATRAAVEEGILPGGGTALLKAAANGLASVKPTSSDQLRRISSLVSAITRPARTIVENAGLEGSVIVGKLTDEHASDFNRGFDSAKGEYVDMIASGIVDPLKVVRTALVDASGVASLLGTTEVAIVEAPEEKGPAGPPGGMGGMGGMGGGMF
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionHsp60
References for functionDeepe Jr, George S., and Reta S. Gibbons. "Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum." Infection and immunity 70.7 (2002): 3759-3767.
E.C. numberN/A
Location of functional site(s)
Cellular location of functionmitochondrion
Comments
Function 2
Function descriptionadhesin
References for functionLong KH, Gomez FJ, Morris RE, Newman SL.Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages. J Immunol. 2003 Jan 1;170(1):487-94. PMID: 12496435
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments