Protein Information

General Information
MoonProt ID7
First appeared in release1.0
Name(s)Hsp60 60 kDa heat shock protein, mitochondrial Hsp60 kDa chaperonin Chaperonin 60 CPN60 Heat shock protein 60 HSP-60 HuCHA60 Mitochondrial matrix protein P1 P60 lymphocyte protein Gene Name: HSPD1
UniProt IDP10809 (CH60_HUMAN)
GO termsGO:0002368 B cell cytokine production GO:0002755 MyD88-dependent toll-like receptor signaling pathway GO:0002842 positive regulation of T cell mediated immune response to tumor cell GO:0006200 ATP catabolic process GO:0006457 protein folding GO:0006458 'de novo' protein folding GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006986 response to unfolded protein GO:0008219 cell death GO:0019048 modulation by virus of host morphology or physiology GO:0032727 positive regulation of interferon-alpha production GO:0032729 positive regulation of interferon-gamma production GO:0032733 positive regulation of interleukin-10 production GO:0032735 positive regulation of interleukin-12 production GO:0032755 positive regulation of interleukin-6 production GO:0042026 protein refolding GO:0042100 B cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0043032 positive regulation of macrophage activation GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0044267 cellular protein metabolic process GO:0048291 isotype switching to IgG isotypes GO:0050821 protein stabilization GO:0050870 positive regulation of T cell activation GO:0051131 chaperone-mediated protein complex assembly GO:0051604 protein maturation GO:0000166 nucleotide binding GO:0001530 lipopolysaccharide binding GO:0002039 p53 binding GO:0003688 DNA replication origin binding GO:0003697 single-stranded DNA binding GO:0005515 protein binding GO:0005524 ATP binding GO:0016887 ATPase activity GO:0051082 unfolded protein binding GO:0051087 chaperone binding GO:0005615 extracellular space GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0005759 mitochondrial matrix GO:0005769 early endosome GO:0005829 cytosol GO:0005886 plasma membrane GO:0005905 coated pit GO:0009986 cell surface GO:0030135 coated vesicle GO:0030141 secretory granule GO:0043231 intracellular membrane-bounded organelle GO:0046696 lipopolysaccharide receptor complex colocalizes_with GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex GO: 0005515 protein binding GO:0070506 high-density lipoprotein particle receptor activity
Organisms for which functions have been demonstratedHomo sapiens
Sequence length573
FASTA sequence>gi|129379|sp|P10809.2|CH60_HUMAN RecName: Full=60 kDa heat shock protein, mitochondrial; AltName: Full=60 kDa chaperonin; AltName: Full=Chaperonin 60; Short=CPN60; AltName: Full=Heat shock protein 60; Short=HSP-60; Short=Hsp60; AltName: Full=HuCHA60; AltName: Full=Mitochondrial matrix protein P1; AltName: Full=P60 lymphocyte protein; Flags: Precursor MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionHsp60 mitochondrial protein import, facilitate correct folding, promote refolding, prevent misfolding of proteins
References for functionSingh, Bhag, et al. "Mitochondrial import of the human chaperonin (HSP60) protein." Biochemical and biophysical research communications 169.2 (1990): 391-396.
E.C. numberN/A
Location of functional site(s)Binding site:75,520,440 Nucleotide binding site:111-115 Active site:127 Binding site:154,162,211,244,11,222 Metal binding site:103 Nucleotide binding site:72-73,102-105
Cellular location of functionmitochondrial matrix
Comments
Function 2
Function descriptionreceptor for HDL affinity for apolipoprotein apoA-II
References for functionBocharov AV, Vishnyakova TG, Baranova IN, Remaley AT, Patterson AP, Eggerman TL. Heat shock protein 60 is a high-affinity high-density lipoprotein binding protein. Biochem Biophys Res Commun. 2000 Oct 14. PMID: 11027668
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments