Protein Information

General Information
MoonProt ID70
First appeared in release1.0
Name(s)Hsp60 60 kDa chaperonin GroEL protein Cpn60 Gene Name: groL
UniProt IDQ5X762 (CH60_LEGPA), Reviewed
GO termsGO:0006457 protein folding GO:0042026 protein refolding GO:0044267 cellular protein metabolic process GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0051082 unfolded protein binding GO:0005737 cytoplasm GO:0005515 protein binding GO:0098631 cell adhesion mediator
Organisms for which functions have been demonstratedLegionella pneumophila
Sequence length548
FASTA sequence>sp|Q5X762|CH60_LEGPA 60 kDa chaperonin OS=Legionella pneumophila (strain Paris) GN=groL PE=3 SV=1 MAKELRFGDDARLQMLAGVNALADAVQVTMGPRGRNVVLEKSYGAPTVTKDGVSVAKEIEFEHRFMNMGAQMVKEVASKTSDTAGDGTTTATVLARSILVEGHKAVAAGMNPMDLKRGIDKAVLAVTKKLQAMSKPCKDSKAIAQVGTISANSDEAIGAIIAEAMEKVGKEGVITVEDGNGLENELSVVEGMQFDRGYISPYFINNQQNMSCELEHPFILLVDKKVSSIREMLSVLEGVAKSGRPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIAILTKGQVISEEIGKSLEGATLEDLGSAKRIVVTKENTTIIDGEGKATEINARIAQIRAQMEETTSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALIRAQKALDSLKGDNDDQNMGINILRRAIESPMRQIVTNAGYEASVVVNKVAEHKDNYGFNAATGEYGDMVEMGILDPTKVTRMALQNAASVASLMLTTECMVADLPKKEEGVGAGDMGGMGGMGGMGGMM
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionchaperone - Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides
References for functionGarduño, Rafael A., Elizabeth Garduño, and Paul S. Hoffman. "Surface-associated hsp60 chaperonin of Legionella pneumophila mediates invasion in a HeLa cell model." Infection and immunity66.10 (1998): 4602-4610.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionadhesin
References for functionGardu?o RA, Gardu?o E, Hoffman PS. Surface-associated hsp60 chaperonin of Legionella pneumophila mediates invasion in a HeLa cell model. Infect Immun. 1998 Oct;66(10):4602-10 PMID: 9746556
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments