Protein Information

General Information
MoonProt ID78
First appeared in release1.0
Name(s)Hsp60 GroEL 60 kDa chaperonin Protein Cpn60 Gene Name: groL
UniProt IDQ9KKF0 (CH60_CLODI), Reviewed
GO termsGO:0006457 protein folding GO:0042026 protein refolding GO:0044267 cellular protein metabolic process GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0051082 unfolded protein binding GO:0005737 cytoplasm GO:0005515 protein binding GO:0098631 cell adhesion mediator
Organisms for which functions have been demonstratedClostridium difficile
Sequence length540
FASTA sequence>gi|8886080|gb|AAF80372.1|AF159449_1 heat shock protein GroEL [[Clostridium] difficile] MAKEIKFSEETRRALEAGVNKLADTVKVTLGPKGRNVILDKKFGSPLITNDGVTIAKEIELEDRFENMGAQLVKEVATKTNDVAGDGTTTATVLAQAIIREGLKNVTAGANPILLRKGIQKAVTVAVEELKNQSRIVETQEAISQVASISAGDEEVGKLIAEAMEIVGKDGVITVEESQTMNTELDAVEGMQFDRGFVSAYMVTDVDKMEAVLKDPYILITDKKISNIQELLPVVEQIVQQGKKLLIIAEDVEGEALSTLVVNKLRGTFDVVAVKAPGFGDRRKEMLQDIAILTGAQVISEELGYDLKEADLSMLGRASSVKVTKENTTIVDGSGDKKSIEDRVTQIKHQVEQTTSDFDREKLMERLAKLAGGVAVVKVGAATEVELKERKLRIEDALNATRAAVEEGIVAGGGTAFVSVIPAIGTLIESLEGEVKLGAQIVKKALEEPLRQIAINAGLEGAVIVQNVVNSEAETGFDALNEKYVNMIEAGIVDPTKVSRSALQNAASIASTFLTTEAAVADLPEKEDAGMPGTGMDGMY
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionchaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteins
References for functionPoilane, Isabelle, et al. "Protease activity of Clostridium difficile strains." Canadian journal of microbiology 44.2 (1998): 157-161.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionadhesin
References for functionHennequin C, Porcheray F, WaligoraDupriet A, Collignon A, Barc M, Bourlioux P, Karjalainen T. GroEL (Hsp60) of Clostridium difficile is involved in cell adherence. Microbiology. 2001 Jan;147(Pt 1):87-96. PMID: 11160803
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments