Protein Information

General Information
MoonProt ID79
First appeared in release1.0
Name(s)Hsp60 HspB 60 kDa chaperonin GroEL protein Protein Cpn60 Gene Name: hspB
UniProt IDQ8RNU2 (Q8RNU2_HELPX), Unreviewed
GO termsGO:0006457 protein folding GO:0006950 response to stress GO:0042026 protein refolding GO:0044267 cellular protein metabolic process GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0051082 unfolded protein binding GO:0005737 cytoplasm GO:0098631 cell adhesion mediator
Organisms for which functions have been demonstratedHelicobacter pylori (H. pylori strain TK1029)
Sequence length546
FASTA sequence>gi|19338968|gb|AAL86900.1|AF479030_1 heat shock protein B subunit [Helicobacter pylori] MAKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIELSCPVANMGAQLVKEVASKTADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMDKAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKLIADAMEKVGKDGVITVEEAKGIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTMKEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAILTGGQVISEELGLSLENAEVEFLGKAGRIVIDKDNTTIVDGKGHSDDVKDRVAQIKTQIASTTSDYDKEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIRAAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVEKHEGHFGFNASNGKYVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKAAPAMPDMGGMGGMGGMGGMM
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionchaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteins
References for functionMacchia, Giovanni, et al. "The Hsp60 protein of Helicobacter pylori: structure and immune response in patients with gastroduodenal diseases." Molecular microbiology 9.3 (1993): 645-652.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionadhesin - to host cells
References for functionKamiya S, Yamaguchi H, Osaki T, Taguchi H. A virulence factor of Helicobacter pylori: role of heat shock protein in mucosal inflammation after H. pylori infection. J Clin Gastroenterol. 1998;27 Suppl 1:S35-9. PMID: 9872496 Yamaguchi H, Osaki T, Kurihara N, Taguchi H, Hanawa T, Yamamoto T, Kamiya S. Heat-shock protein 60 homologue of Helicobacter pylori is associated with adhesion of H. pylori to human gastric epithelial cells. J Med Microbiol. 1997 Oct;46(10):825-31. PMID: 9364138
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments