Protein Information

General Information
MoonProt ID8
First appeared in release1.0
Name(s)GroEL 60 kDa chaperonin Protein Cpn60 Gene Name:groL
UniProt IDO66198 (CH60_ENTAK), Reviewed
GO termsGO:0006457 protein folding GO:0042026 protein refolding GO:0044267 cellular protein metabolic process GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0051082 unfolded protein binding GO:0005737 cytoplasm GO: 0090729 toxin activity
Organisms for which functions have been demonstratedEnterobacter aerogenes
Sequence length548
FASTA sequence>sp|O66198|CH60_ENTAK 60 kDa chaperonin OS=Enterobacter aerogenes (strain ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006) GN=groL PE=3 SV=2 MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVVAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLEDELDVVEGMQFDRGYLSPYFINKPDTGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLVIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRKQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVDDALHATRAAVEEGVVAGGGVALVRVAAKIAGLTGQNEDQNVGIKVALRAMEAPLRQIVSNAGEEPSVVANNVKAGDGNYGYNAATEEYGNMIDFGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKGDAPDLGAAGGMGGMGGMGGMM
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionprotein chaperone, prevents proteins from misfolding, promotes correct refolding and assembly of polypeptides
References for functionBraig, Kerstin, et al. "The crystal structure of the bacterial chaperonln GroEL at 2.8 Å." Nature 371.6498 (1994): 578-586.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptiontoxin, paralyzes cockroaches (produced by bacterium that is an endosymbiont of antlions, which are larvae of Myrmeleon bore)
References for functionYoshida N, Oeda K, Watanabe E, Mikami T, Fukita Y, Nishimura K, Komai K, Matsuda K. Protein function. Chaperonin turned insect toxin. Nature. 2001 May 3;;411(6833):44. PMID: 11333970
E.C. numberN/A
Location of functional site(s)
Cellular location of functionsecreted
Comments