Protein Information

General Information
MoonProt ID80
First appeared in release1.0
Name(s)Hsp65 Cpn60.2 GroEL2 groEL 60 kDa chaperonin GroEL protein Gene Name: groL
UniProt IDA0A0H3LCC3
GO termsGO:0006457 protein folding GO:0042026 protein refolding GO:0044267 cellular protein metabolic process GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0051082 unfolded protein binding GO:0005737 cytoplasm GO:0005515 protein binding GO:0098631 cell adhesion mediator
Organisms for which functions have been demonstratedMycobacterium tuberculosis
Sequence length540 aa
FASTA sequence>tr|A0A0H3LCC3|A0A0H3LCC3_MYCTE 60 kDa chaperonin OS=Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) GN=groEL PE=3 SV=1 MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionchaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteins
References for functionPlikaytis, Bonnie B., et al. "Differentiation of slowly growing Mycobacterium species, including Mycobacterium tuberculosis, by gene amplification and restriction fragment length polymorphism analysis." Journal of Clinical Microbiology 30.7 (1992): 1815-1822.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionadhesin to CD43 on macrophage surface
References for functionHickey TB, Thorson LM, Speert DP, Daff M, Stokes RW. Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages. Infect Immun. 2009 Aug;77(8):3389-401. doi: 10.1128/IAI.00143-09. Epub 2009 May 26. PMID: 19470749
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments