Protein Information

General Information
MoonProt ID85
First appeared in release1.0
Name(s)Phosphoglycerate kinase Gene Name: pgk
UniProt IDQ8DXT0
GO termsGO:0006096 glycolysis GO:0016310 phosphorylation GO:0000166 nucleotide binding GO:0004618 phosphoglycerate kinase activity GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0005737 cytoplasm GO:0005515 protein binding
Organisms for which functions have been demonstratedStreptococcus agalactiae (GBS = group B Streptococcus, strain NCS13)
Sequence length398 aa
FASTA sequence>sp|Q8DXT0|PGK_STRA5 Phosphoglycerate kinase OS=Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) GN=pgk PE=3 SV=1 MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEEADKEGKSLAPVAADLAAKLGQDVVFPGVTRGAKLEEAINALEDGQVLLVENTRFEDVDGKKESKNDEELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKDLLEKSNGKLILPVDSKEANAFAGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionPhosphoglycerate kinase ADP + 1,3-bisphosphoglycerate => ATP + 3-phosphoglycerate Carbohydrate degradation, glycolysis
References for functionCarlsson, J., Y. Iwami, and T. Yamada. "Hydrogen peroxide excretion by oral streptococci and effect of lactoperoxidase-thiocyanate-hydrogen peroxide." Infection and Immunity 40.1 (1983): 70-80.
E.C. number2.7.2.3
Location of functional site(s)Binding site:296,119,208,327,36,157 Nucleotide binding site:354-357
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionplasminogen binding
References for functionBoone TJ, Burnham CA, Tyrrell GJ. Binding of group B streptococcal phosphoglycerate kinase to plasminogen and actin.Microb Pathog. 2011 Oct;51(4):255-61. doi: 10.1016/j.micpath.2011.06.005. Epub 2011 Jun 28. PMID: 21729749
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments