Protein Information

General Information
MoonProt ID86
First appeared in release1.0
Name(s)Phosphoglycerate kinase Gene Name: pgk
UniProt IDQ8DQX8 (PGK_STRR6), Reviewed
GO termsGO:0006096 glycolysis GO:0016310 phosphorylation GO:0000166 nucleotide binding GO:0004618 phosphoglycerate kinase activity GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0005737 cytoplasm GO:0005515 protein binding
Organisms for which functions have been demonstratedStreptococcus pneumoniae
Sequence length398
FASTA sequence>sp|Q8DQX8|PGK_STRR6 Phosphoglycerate kinase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) GN=pgk PE=1 SV=1 MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEESDKAGKSLAPVAADLAAKLGQDVVFPGVTRGAELEAAINALEDGQVLLVENTRYEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLILPVDSKEANAFAGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionPhosphoglycerate kinase, enzyme ADP + 1,3-bisphosphoglycerate => ATP + glycerate-3-phosphate Carbohydrate degradation, glycolysis
References for functionLing, E., et al. "Glycolytic enzymes associated with the cell surface of Streptococcus pneumoniae are antigenic in humans and elicit protective immune responses in the mouse." Clinical & Experimental Immunology 138.2 (2004): 290-298.
E.C. number2.7.2.3
Location of functional site(s)Binding site:296,119,208,327,36,157 Nucleotide binding site:354-357
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionplasminogen binding
References for functionFulde M, BernardoGarc?a N, Rohde M, Nachtigall N, Frank R, Preissner KT, Klett J, Morreale A, Chhatwal GS, Hermoso JA, Bergmann S. Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator. Thromb Haemost. 2014 Mar 3;111(3):401-16. doi: 10.1160/TH13-05-0421. Epub 2013 Nov 7. PMID: 24196407
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments