Protein Information

General Information
MoonProt ID94
First appeared in release1.0
Name(s)Pyruvate-ferredoxin oxidoreductase PFO Pyruvate:ferredoxin oxidoreductase proprotein Gene Name: pfoB
UniProt IDQ27089 (Q27089_TRIVA), Unreviewed
GO termsGO:0008152 metabolic process GO:0022900 electron transport chain P GO:0055114 oxidation-reduction process GO:0003824 catalytic activity GO:0005506 iron ion binding GO:0016491 oxidoreductase activity GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors GO:0030976 thiamine pyrophosphate binding GO:0051536 iron-sulfur cluster binding GO:0098631 cell adhesion mediator activity
Organisms for which functions have been demonstratedTrichomonas vaginalis
Sequence length
FASTA sequence>gi|622960|gb|AAA85495.1| pyruvate:ferredoxin oxidoreductase proprotein [Trichomonas vaginalis] MLRNFSKRVPGDGNTAATSVAYQLTETSFIYPITPATTMGELVDAWIAQGRKNIWGNKVNMAMMQSEGGAAAAVHGATAVGALCATFTASQGALLMIPDMYKIVGEMCPAVFHIAARCIATSALSIYNDHGDIYACRATGMPILFSNGVQEAHDLAAVAHLTSIHTGLPFIHTFDGFRTSHEINTYEELDNETLWPLIDQKALAAFRARSLNPEHPSERGTICGPEYVWQMHEKLRKPYQALPAEVEKMMKALGDKTGRYYKPYQYAGPRDPENVIIMMGSGCDPVEEFITEHPEYKTGLIKVYLYRPFSVEMFNAAIPSSVKRVCVLDKVVDPTGPREPLFEDVAAAIIGQRNVKIIGGRYGISSRDFAPVHVEAIVKNLVSQIPKDRFTVGVVNPETALPLGKPFDHLPEGTKQCMFWGLGSDGTVGANKQAIKLIVSNTKLYGQAYFAYDAHKSGGVTTSHLRFGAKPINAPYYVQNADYIACHNPSYLHKFDMTKQLKQGGVFVINFPGNLDLNKDLPGSFRRSIAEKDAKLYTIDATQIAIDLKLPGRINMLMQTVFFGLANIIPAEECIALLKKSIAKQYARKGKEVIQKNWDMVDHALQGLKEFKYNKAEWLNAPVEPRPKHEGIRHIIDMSILQEGESVSVDEMVDIGLVPNGTAKFEKRGIAVTVPKWDEKKCIQCNTCAMVCPHAVICPFLLKPEEVQGLTTLKAKGKEIKDYQFRIQITPLDCTGCGTCVTSCPTKALSMTYRNAKLDEEEGKNWERLTAIPNRGHLVPATNVRNVQFRQPLIEFNGACQGCGETAICKLLTQLYGDQLYLANATGCSLVWGATFPFNPYTTNERGHGPAWANSLFEDNAEFGYGMFKAVEARRNITKRLIVDVIESGEVKGELKDLFEQLLKVWDQDKESGDLAEKIKPLLAKVQNPSEKLFDLKSQADILAKKQVWIVGGDGWAYDIGYGGLDHVLASGENVKIIIYDTEVYSNTGGQCSKATSRGAVANFSAAGYTKAKKDLGAIAMTYKNIYVASTCLLADPNQALKALQEAKEYNGPAIIINYSPCINHGIKKGLGSTPKHCKDLLKTGYLNLFRYNPSKDKPLTVDTKQPDYNLDPLVKGENRFAALKDIYPKEAETKFPLLINDMKTRYEGYKKIQQTQ
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionPyruvate-ferredoxin oxidoreductase, enzyme oxidative decarboxylation of pyruvate to yield acetyl-CoA and CO2
References for functionWilliams, K., P. N. Lowe, and P. F. Leadlay. "Purification and characterization of pyruvate: ferredoxin oxidoreductase from the anaerobic protozoon Trichomonas vaginalis." Biochemical Journal246.2 (1987): 529-536.
E.C. number1.2.7.1
Location of functional site(s)Metal binding site:688,685,1062,800,803,692,682,740,828,744,734,737
Cellular location of function on the membranes of hydrogenosome
Comments
Function 2
Function descriptioncell surface adherance protein
References for functionMoreno-Brito, V., Yanez-Gomez, C., Meza-Cervantez, P., Avila-Gonzalez, L., Rodriguez, M. A., Ortega-Lopez, J., Gonzalez-Robles, A. and Arroyo, R. (2005). A Trichomonas vaginalis 120 kDa protein with identity to hydrogenosome pyruvate:ferredoxin oxidoreductase is a surface adhesin induced by iron.Cell Microbiol. 2005 Feb;7(2):245-58. PMID: 15659068
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments