Protein Information

General Information
MoonProt ID99
First appeared in release1.0
Name(s)Fructose 1,6-bisphosphate Aldolase Fructose-bisphosphate aldolase FBP aldolase FBPA Gene Name:FBA1
UniProt IDP14540 (ALF_YEAST), Reviewed
GO termsGO:0005975 carbohydrate metabolic process GO:0006094 gluconeogenesis GO:0006096 glycolytic process GO:0003824 catalytic activity GO:0004332 fructose-bisphosphate aldolase activity GO:0008270 zinc ion binding GO:0016829 lyase activity GO:0016832 aldehyde-lyase activity GO:0046872 metal ion binding GO:0005739 mitochondrion GO:0005829 cytosol GO:0005515 protein binding
Organisms for which functions have been demonstratedSaccharomyces cerevisiae
Sequence length359
FASTA sequence>sp|P14540|ALF_YEAST Fructose-bisphosphate aldolase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FBA1 PE=1 SV=3 MGVEQILKRKTGVIVGEDVHNLFTYAKEHKFAIPAINVTSSSTAVAALEAARDSKSPIILQTSNGGAAYFAGKGISNEGQNASIKGAIAAAHYIRSIAPAYGIPVVLHSDHCAKKLLPWFDGMLEADEAYFKEHGEPLFSSHMLDLSEETDEENISTCVKYFKRMAAMDQWLEMEIGITGGEEDGVNNENADKEDLYTKPEQVYNVYKALHPISPNFSIAAAFGNCHGLYAGDIALRPEILAEHQKYTREQVGCKEEKPLFLVFHGGSGSTVQEFHTGIDNGVVKVNLDTDCQYAYLTGIRDYVLNKKDYIMSPVGNPEGPEKPNKKFFDPRVWVREGEKTMGAKITKSLETFRTTNTL
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionAldolase, enzyme D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate Glycolysis, Gluconeogenesis
References for functionSCHWELBERGER, Hubert Gernot, Sepp Dieter KOHLWEIN, and Fritz PALTAUF. "Molecular cloning, primary structure and disruption of the structural gene of aldolase from Saccharomyces cerevisiae." The FEBS Journal 180.2 (1989): 301-308.
E.C. number4.1.2.13
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds to vacuolar H+-ATPase and is needed for its assembly enzymatic catalytic activity not needed for this function
References for functionLu M, Holliday LS, Zhang L, Dunn WA, Gluck SL. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. J Biol Chem. 2001 Aug 10. PMID: 11399750. Lu M, Sautin YY, Holliday LS, Gluck SL. The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase. J Biol Chem. 2004 Mar 5. PMID: 14672945. Lu M, Ammar D, Ives H, Albrecht F, Gluck SL. Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump. J Biol Chem. 2007 Aug 24. PMID: 17576770.
E.C. numberN/A
Location of functional site(s)
Cellular location of functionmitochondrion
Comments