Protein Information

General Information
MoonProt ID260
First appeared in release1.0
Name(s)MDR1 Multidrug resistance protein 1 ATP-binding cassette sub-family B member 1 P-glycoprotein 1 CD_antigen=CD243 Gene Name:ABCB1
UniProt IDP08183 (MDR1_HUMAN), Reviewed
GO termsGO:0000086 G2/M transition of mitotic cell cycle GO:0006200 ATP catabolic process GO:0006810 transport GO:0006855 drug transmembrane transport GO:0042493 response to drug GO:0042908 xenobiotic transport GO:0044281 small molecule metabolic process GO:0055085 transmembrane transport GO:0072089 stem cell proliferation GO:0000166 nucleotide binding GO:0005215 transporter activity GO:0005515 protein binding GO:0005524 ATP binding GO:0008559 xenobiotic-transporting ATPase activity GO:0016787 hydrolase activity GO:0016887 ATPase activity GO:0017111 nucleoside-triphosphatase activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0000139 Golgi membrane GO:0005886 plasma membrane GO:0009986 cell surface GO:0016020 membrane GO:0016021 integral component of membrane GO:0016324 apical plasma membrane GO:0046581 intercellular canaliculus GO:0070062 extracellular vesicular exosome GO:0099106 ion channel regulator activity
Organisms for which functions have been demonstratedHomo sapiens
Sequence length1280
FASTA sequence>sp|P08183|MDR1_HUMAN Multidrug resistance protein 1 OS=Homo sapiens GN=ABCB1 PE=1 SV=3 MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptiontransmembrane transporter efflux pump, uses ATP for energy expels drugs and other small molecule compounds ATP + H2O + xenobiotic(Inside) => ADP + phosphate + xenobiotic(Outside)
References for functionChen, Chang-jie, et al. "Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells." Cell 47.3 (1986): 381-389.
E.C. number3.6.3.44
Location of functional site(s)nucleotide binding: 427-434, 1070-1077
Cellular location of functionplasma membrane, transmembrane protein
Comments
Function 2
Function descriptionregulator of volume-activated chloride channels
References for functionHardy SP, Goodfellow HR, Valverde MA, Gill DR, Sep?lveda V, Higgins CF. Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels. EMBO J. 1995 Jan 3;14(1):68-75. PMID: 7828597
E.C. numberN/A
Location of functional site(s)
Cellular location of functionplasma membrane, transmembrane protein
Comments