Proteins

ID Protein Name Function 1 Function 2 Species Name
1Fructose-1,6-bisphosphate aldolaseFructose-1,6-bisphosphate aldolasetranscription regulatorFrancisella tularensis
2RfaH, Escherichia coliaids in transcription elongation of long RNA chains, reduces pausing and inhibits termination translational regulatorEscherichia coli
3SMC-3 (Structural maintenance chromosome 3), Mus musculusSMC3 interacts with SMC1 and other non-Smc subunits like Scc3 and Scc1 (also called Rad21) to form a cohesion complex, called "cohesin," that maintains proper sister chromatid cohesion throughout the cell cycle and during mitosis to ensure accurate chromosome segregation. Each Smc heterodimer associates with non-Smc subunits to form functional Smc complexes.Bamacan is a proteoglycan, and is a component of a component of the basement membrane in the Engelbreth-Holm-Swarm tumor matrix, the renal mesangial matrix, and the basement membrane of other tissues. Bamacan is involved in the control of cell growth and transformationMus musculus (Mouse)
4FdGOGAT Glutamate synthase, Spinacia oleracea FdGOGAT Glutamate synthase, enzyme 2 L-glutamate + 2 oxidized ferredoxin => L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. amino acid biosynthesis, L-glutamate biosynthesisSubunit of UDP-sulfoquinovose synthaseSpinacia oleracea (Spinach)
51-Cys Peroxiredoxin, Homo sapiensAcidic calcium-independent Phospholipase A2 (aiPLA2): regulation of phospholipid turnoverNon-selenium Glutathione Peroxidase Can reduce H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxidesHomo sapiens
6Phosphoglucose Isomerase, Mus musculusCatalyzes interconversion of glucose-6-phosphate and fructose-6-phosphate in glycolysis and gluconeogenesisCytokine/growth factor, binds to target cells and causes pre-B cells to mature into antibody secreting cells, supports survival of embryonal neurons, causes differentiation of some leukemia cell linesMus musculus (mouse)
7Hsp60, Homo sapiensHsp60 mitochondrial protein import, facilitate correct folding, promote refolding, prevent misfolding of proteins receptor for HDL affinity for apolipoprotein apoA-IIHomo sapiens
8GroEL, Enterobacter aerogenesprotein chaperone, prevents proteins from misfolding, promotes correct refolding and assembly of polypeptides toxin, paralyzes cockroaches (produced by bacterium that is an endosymbiont of antlions, which are larvae of Myrmeleon bore)Enterobacter aerogenes
96-phosphofructokinase, Lactococcus lactis6-phosphofructokinase, enzyme ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphate Carbohydrate degradation, glycolysis binding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiaeLactococcus lactis IL1403
106-phosphofructokinase, Streptococcus oralis6-phosphofructokinase, enzyme ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphate Carbohydrate degradation, glycolysisbinds plasminogen from host organismStreptococcus oralis LA11 - oral streptococci
11S3 ribosomal protein, Homo sapienribosomal protein, part of the 40S subunita subunit of a DNA binding complex involved in NF-kappaB-mediated transcriptionHomo sapiens
126-phosphogluconate dehydrogenase , Streptococcus6-phosphogluconate dehydrogenase, enzyme 6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH Carbohydrate degradation, pentose phosphate pathway adhesin - not clear to which host proteinStreptococcus pneumoniae
13Alcohol dehydrogenase (ADH1), Candida albicansAlcohol dehydrogenase (ADH1), enzyme An alcohol + NAD+ => an aldehyde or ketone + NADH. binds plasminogen from humansCandida albicans
14alcohol acetaldehyde dehydrogenase, ListeriaAn enzyme: The N-terminus contains acetaldehyde dehydrogenase (ALDH) and the Cterminus an alcohol dehydrogenase (ADH) Adhesin, binds Hsp60 on surface of host cellsListeria monocytogenes
15alcohol dehydrogenase (EhADH2), Enteamoeba histolytica alcohol dehydrogenase (EhADH2), enzyme Including the following 2 domains: Alcohol dehydrogenase and Acetaldehyde dehydrogenase An alcohol + NAD+ => an aldehyde or ketone + NADH Acetaldehyde + CoA + NAD+ => acetyl-CoA + NADH. demonstrated that it has both ADH and acetaldehyde dehydrogenase activity. binds fibronectin, laminin, and type II collagen Enteamoeba histolytica
16Aspartate ammonia lyase, aspartase, Haemophilus influenzaeaspartate ammonia lyase, aspartase, enzyme L-aspartate => fumarate + NH3binds plasminogenHaemophilus influenzae strain HI-23459
17Bile salt hydrolase, Bifidobacteriumbile salt hydrolaseplasminogen bindingBifidobacterium(Bifidobacterium lactis, B. bifidum, and B. longum
18DnaK, Bifidobacteriumchaperoneplasminogen bindingBifidobacterium(Bifidobacterium lactis, B. bifidum, and B. longum)
19DnaK, Lactococcus lactischaperonebinding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiaeLactococcus lactis IL1403
20DnaK, Neisseria meningitidischaperoneplasminogen binding proteinNeisseria meningitidis
21DnaK, Mycobacterium tuberculosischaperone plasminogen bindingMycobacterium tuberculosis H37Rv (ATCC no. 27294)
22Ef-Tu, Lactobacillus johnsoniielongation factor in protein synthesisattachment to human cells and mucinsLactobacillus johnsonii NCC533 (La1)
23Ef-Tu, Mycoplasma pneumoniaeelongation factor in protein synthesis during protein biosynthesis: promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes fibronectin bindingMycoplasma pneumoniae
24Ef-Tu, Pseudomonas aeruginosaelongation factor during protein synthesis during protein synthesis: promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes factor H and plasminogen bindingPseudonomas aeruginosa
25enolase, Aeromonas hydrophilaenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. Carbohydrate degradation, glycolysis plasminogen binding (binds human plasminogen)Aeromonas hydrophila
26enolase, Bifidobacteriumenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisplasminogen binding (binds human plasminogen)Bifidobacterium (B. longum, B. bifidum, B. breve and B. lactis) - health-promoting member of the human intestinal microbiota
27enolase, Borrelia burgdorferi enolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. Carbohydrate degradation, glycolysisplasminogen binding (binds human plasminogen)Borrelia burgdorferi
28enolase, Candida albicansenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysis plasminogen bindingCandida albicans
29Enolase, Lactobacillus crispatusEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O. Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysis; binds plasminogen and lamininLactobacillus crispatus
30Enolase, Lactobacillus johnsonii2-phospho-D-glycerate => phosphoenolpyruvate + H2O. Pathway Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogen and lamininLactobacillus johnsonii
31Enolase, Lactobacillus plantarumEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysis binds fibronectinLactobacillus plantarum
32Enolase, Neisseria meningitidisEnolase 2-phospho-D-glycerate => phosphoenolpyruvate + H2O. Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisplasminogen bindingNeisseria meningitidis
33Enolase, Onchocerca volvulusEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogenOnchocerca volvulus
34Enolase, Staphylococcus aureusEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogen and lamininStaphylococcus aureus
35Enolase, Oral streptococci (S. anginosus, S. oralis)Enolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisplasminogen bindingEnolase, Oral streptococci (S. anginosus, S. oralis)
36Enolase, Streptococcus pneumoniaeenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogen Streptococcus pneumoniae
37Enolase, Streptococcus pyogenesenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogen Streptococcus pyogenes
38enolase, Streptococcus suisenolase 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds fibronectin and plasminogenStreptococcus suis
39Enolase, Streptococcus mutansEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogenStreptococcus mutans
40Enolase, Homo sapiensenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysis plasminogen bindingHomo sapiens
41Enolase, Trichomonas vaginalisEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysisplasminogen bindingTrichomonas vaginalis
42Enolase, Rattus norvegicusEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysis plasminogen bindingRattus norvegicus
43Enolase, Leishmania mexicanaenolase, enzyme reversible conversion of 2-phosphoglycerate to phosphoenolpyruvatebinds plasminogenLeishmania mexicana
44Enolase, Paracoccidioides brasiliensisenolase, enzyme catalyses the dehydration of 2-phospho-D-glycerate (PGA) to phosphoenolpyruvate glycolysis, gluconeogenesisfibronectin bindingParacoccidioides brasiliensis
45Enolase, Bacillus anthracisenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogen and lamininBacillus anthracis
46Fructose bisphosphate aldolase, Candida albicansFructose bisphosphate aldolase, enzyme D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis Carbohydrate degradation, glycolysis, gluconeogenesis plasminogen bindingCandida albicans
47fructose-1,6-bisphosphate aldolase, Neisseria meningitidisfructose-1,6-bisphosphate aldolase, enzymeadhesin to human cellsNeisseria meningitidis
49GAPDH, Lactobacillus plantarumGAPDH, enzyme Glyceraldehyde 3-phosphate dehydrogenase binds mucin and Caco-2 cellsLactobacillus plantarum
50GAPDH, Lactococcus lactisglyceraldehyde 3-phosphate dehydrogenase, GAPDH, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphospho-D-glycerate + NADH. Carbohydrate degradation, glycolysisbinding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiaeLactococcus lactis IL1403
51GAPDH, Paracoccidioides brasiliensisglyceraldehyde 3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphosphoglycerate + NADH. Carbohydrate degradation, glycolysisbind to fibronectin, laminin, and type I collagenParacoccidioides brasiliensis
52GAPDH, Oral streptococci (S. anginosus and S. oralis)GAPDH, Glyceraldehyde-3-phosphate dehydrogenase, enzymeplasminogen bindingOral streptococci (S. anginosus and S. oralis)
53GAPDH, Streptococcus pyogenes glyceraldehyde 3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ => 1,3-bisphosphoglycerate + NADH. Carbohydrate degradation, glycolysisbinds uPAR/CD87 receptor on human cellsStreptococcus pyogenes
54GAPDH, Streptococcus suisGAPDH, glyceraldehyde 3-phosphate dehydrogenase, enzymeplasminogen bindingStreptococcus suis (serotype 2)
55GAPDH, Trichomonas vaginalisGlyceraldehyde-3-phosphate dehydrogenase, enzymebinds fibronectin fibronectin binding, and plasminogen and collagenTrichomonas vaginalis
56GAPDH, Staphylococcus aureus (S. epidermidis and S. aureus)GAPDH, glyceraldehyde 3-phosphate dehydrogenase, enzymetransferrin-binding protein (also called TPN) AND also binds plasminogen involved in the acquisition of transferrin-bound ironStaphylococcus aureus (S. epidermidis and S. aureus)
57GAPDH, Streptococcus pneumoniaeglyceraldehyde 3-phosphate dehydrogenase, enzymeplasminogen bindingStreptococcus pneumoniae
58GAPDH, Candida albicansglyceraldehyde 3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphosphoglycerate + NADH. Carbohydrate degradation, glycolysisplasminogen binding fibronectin and laminin binding Candida albicans
59GAPDH, Streptococcus agalactiaeGlyceraldehyde 3-phosphate dehydrogenase, enzymeplasminogen bindingStreptococcus agalactiae, Streptococcus - group B, serotype III/deltaepsilon, strain J48
60GAPDH, Bacillus anthracisglyceraldehyde 3-phosphate dehydrogenase, enzyme catalyzes the oxidative phosphorylation of D-glyceraldehyde- 3-phosphate (G-3-P) to 1,3-diphosphoglycerate in the presence of NAD+/NADP+ and inorganic phosphate (Pi)plasminogen bindingBacillus anthracis
61GAPDH, Mycoplasma genitaliumglyceraldehyde 3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphosphoglycerate + NADH Carbohydrate degradation, glycolysisbinds mucinMycoplasma genitalium
62GAPDH, Streptococcus - group A streptococciglyceraldehyde 3-phosphate dehydrogenase, enzymePlasminogen bindingStreptococcus - group A streptococci, group A streptococcal strain 64/14
63Glutamine synthetase, BifidobacteriumGlutamine synthetase, enzyme ATP + L-glutamate + NH3 => ADP + phosphate + L-glutamineplasminogen bindingBifidobacterium (Bifidobacterium lactis, B. bifidum, and B. longum)
64Glucose 6-phosphate isomerase, Lactobacillus crispatusglucose 6-phosphate isomerase, enzyme D-glucose 6-phosphate <=> D-fructose 6-phosphate Carbohydrate biosynthesis; gluconeogenesis Carbohydrate degradation; glycolysislaminin, collagen I binding (not fibronectin)Lactobacillus crispatus
65Phosphofructokinase, Pichia pastorisphosphofructokinase, enzyme ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphate Glycolysisprotein, but not catalytic function, is required for microautophagy (vacuolar degradation of peroxisomes) only alpha subunit of phosphofructokinase plays this roleKomagataella pastoris (Yeast) (Pichia pastoris)
66Glutamine synthetase, Mycobacterium tuberculosisGlutamine synthetase ATP + L-glutamate + NH3 => ADP + phosphate + L-glutamineplasminogen and fibronectin binding proteinMycobacterium tuberculosis H37Rv (ATCC no. 27294)
67Histone H1, Mus musculusHistone H1 binds to DNA near nucleosomes aids in condensation of nucleosome chains into higher-order structured fibersthyroglobulin receptorMus musculus
68Hsp60, Chlamydiae pneumoniaechaperonin, assist in the correct folding of new or unfolded proteins under both normal and stress conditionsbinding to cell surface and activates pathwaysChlamydiae pneumoniae
69Hsp60, Histoplasma capsulatumHsp60adhesinHistoplasma capsulatum (Hc strain G217B) - also known as Ajellomyces capsulatus
70Hsp60, Legionella pneumophilachaperone - Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides adhesinLegionella pneumophila
71Enolase 1, Saccharomyces cerevisiaeenolase, enzyme 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O Glycolysisrequired for vacuole homotypic membrane fusion and protein trafficking to the vacuole enzyme catalytic activity not needed for this roleSaccharomyces cerevisiae
72Hsp60 chaperone, ListeriaHsp60 chaperoneadhesinListeria
73Hsp60, Haemophilus ducreyiHsp60, GroEL, Prevents misfolding and promotes the refolding and proper assembly of unfolded proteinsadhesin - to glycosphinngolipidsHaemophilus ducreyi
74Hsp60, Lactobacillus johnsoniiHsp60, GroEL, Prevents misfolding of proteins, promotes the refolding and correct assembly of unfolded proteinsadhesin binds to mucins and epithelial cellsLactobacillus johnsonii La1 (NCC 533)
75Hsp60, Lactococcus lactischaperonin, Prevents misfolding of proteins, promotes the refolding and proper assembly of unfolded proteinsbinding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiaeLactococcus lactis IL1403
76Enolase 2, Saccharomyces cerevisiaeenolase, enzyme 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O Glycolysisrequired for vacuole homotypic membrane fusion and protein trafficking to the vacuole enzyme catalytic activity not needed for this roleSaccharomyces cerevisiae
77Hsp60, Salmonella typhimuriumchaperonin, Prevents misfolding of proteins, promotes the refolding and proper assembly of unfolded proteins adhesinSalmonella typhimurium
78Hsp60, Clostridium difficilechaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteinsadhesinClostridium difficile
79Hsp60, Helicobacter pylori chaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteinsadhesin - to host cellsHelicobacter pylori (H. pylori strain TK1029)
80Hsp65, Mycobacterium tuberculosis chaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteinsadhesin to CD43 on macrophage surfaceMycobacterium tuberculosis
81Malate synthase, Mycobacterium tuberculosisMalate synthase, enzyme Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA Acetyl-CoA + H2O + glyoxylate => malate + CoA Carbohydrate metabolism; glyoxylate cycle glyoxylate pathway enables bacteria to assimilate two-carbon compounds into the TCA cycle binds fibronectin and laminin and A549 lung epithelial cellsMycobacterium tuberculosis
82Ornithine carbamoyltransferase, Staphylococcus epidermidisOrnithine carbamoyltransferase, enzyme Carbamoyl phosphate + L-ornithine => phosphate + L-citrullinebind fibronectinStaphylococcus epidermidis
83Peroxiredoxin, Neisseria meningitidisPeroxiredoxin, antioxidantplasminogen bindingNeisseria meningitidis
84Peroxisomal catalase (CTA1), Candida albicansPeroxisomal catalase (CTA1), protect cells from the toxic effects of hydrogen peroxide 2 H2O2 => O2 + 2 H2O plasminogen bindingCandida albicans
85Phosphoglycerate kinase, Streptococcus agalactiaePhosphoglycerate kinase ADP + 1,3-bisphosphoglycerate => ATP + 3-phosphoglycerate Carbohydrate degradation, glycolysisplasminogen bindingStreptococcus agalactiae (GBS = group B Streptococcus, strain NCS13)
86Phosphoglycerate kinase, Streptococcus pneumoniaePhosphoglycerate kinase, enzyme ADP + 1,3-bisphosphoglycerate => ATP + glycerate-3-phosphate Carbohydrate degradation, glycolysisplasminogen bindingStreptococcus pneumoniae
87Phosphoglycerate kinase, Candida albicansPhosphoglycerate kinase, enzyme ADP + 1,3-bisphosphoglycerate => ATP + 3-phospho-D-glycerate Carbohydrate degradation, glycolysisplasminogen binding Candida albicans
88Phosphoglycerate kinase, Streptococcus - oral streptococci (S. anginosus and S. oralis) Phosphoglycerate kinase, enzyme ADP + 1,3-bisphosphoglycerate => ATP + 3-phospho-D-glycerate Carbohydrate degradation, glycolysisplasminogen bindingStreptococcus - oral streptococci (S. anginosus and S. oralis)
89Phosphoglycerate mutase, BifidobacteriumPhosphoglycerate mutase, enzyme 1,3-bisphosphoglycerate <=> 2,3-bisphosphoglycerateplasminogen bindingBifidobacterium (Bifidobacterium lactis, B. bifidum, and B. longum)
90Phosphoglycerate mutase, Streptococcus - oral streptococci (S. anginosus and S. oralis)Phosphoglycerate mutase, enzyme 1,3-bisphosphoglycerate <=> 2,3-bisphosphoglycerateplasminogen bindingStreptococcus - oral streptococci (S. anginosus and S. oralis)
91Phosphoglyceromutase, Candida albicansPhosphoglyceromutase, enzyme 1,3-bisphosphoglycerate <=> 2,3-bisphosphoglycerate Carbohydrate degradation, glycolysisplasminogen bindingCandida albicans
92Pyruvate dehydrogenase, Mycoplasma pneumoniaePyruvate dehydrogenase, enzyme The pyruvate dehydrogenase complex catalyzes the overall conversion pyruvate => acetyl-CoA and CO2. Pyruvate dehydrogenase (E1) is one of the enzyme components of the complex fibrinogen bindingMycoplasma pneumoniae
93Pyruvate kinase, Lactococcus lactisPyruvate kinase, enzyme ADP + phosphoenolpyruvate => ATP + pyruvate Carbohydrate degradation, glycolysisbinding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiaeLactococcus lactis IL1403
94Pyruvate-ferredoxin oxidoreductase, Trichomonas vaginalisPyruvate-ferredoxin oxidoreductase, enzyme oxidative decarboxylation of pyruvate to yield acetyl-CoA and CO2cell surface adherance proteinTrichomonas vaginalis
95Transcription elongation factor, Candida albicansTranscription elongation factor during protein biosynthesis, TEF1 promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of the ribosome plasminogen bindingCandida albicans
96Superoxide dismutase, Mycobacterium aviumSuperoxide dismutase, enzyme antioxidant convert superoxide anion radicals into O2 and H2O2adhesinMycobacterium avium
97Thiol-specific antioxidant protein, Candida albicansThiol-specific antioxidant protein antioxidant 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. plasminogen bindingCandida albicans
98Triose phosphate isomerase, Paracoccidioides brasiliensis Triose phosphate isomerase, enzyme D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate Carbohydrate degradation glycolysis Carbohydrate biosynthesis, gluconeogenesis adhesinParacoccidioides brasiliensis
99Fructose 1,6-Bisphosphate Aldolase, Saccharomyces cerevisiaeAldolase, enzyme D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate Glycolysis, Gluconeogenesisbinds to vacuolar H+-ATPase and is needed for its assembly enzymatic catalytic activity not needed for this functionSaccharomyces cerevisiae
100Triose phosphate isomerase, Staphylococcus aureusTriose phosphate isomerase, enzyme D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate Carbohydrate degradation, glycolysis Carbohydrate biosynthesis, gluconeogenesis adhesin, contact-mediated killing of CryptococcusStaphylococcus aureus
101Triose phosphate isomerase, Streptococcus - oral streptococci (S. anginosus and S. oralis)Triose phosphate isomerase, enzyme D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate Carbohydrate degradation, glycolysis Carbohydrate biosynthesis, gluconeogenesis plasminogen bindingStreptococcus - oral streptococci (S. anginosus and S. oralis)
110Aconitase, Mycobacterium tuberculosisaconitase, enzyme catalyse the isomerization of citrate to iso-citrate in the citric acid cycleiron-responsive protein Binds to selected IREs (Iron-responsive elements)--sequences present within the UTR (untranslated regions) of M. tuberculosis mRNA Mycobacterium tuberculosis
111Aconitase, Saccharomyces cerevisiaeaconitase, enzyme Catalyzes the conversion of citrate to aconitate in the pathway for lysine biosynthesis. Krebs cycle, Amino-acid biosynthesis, L-lysine biosynthesis mitochondrial DNA maintenance enzymatic activity and iron sulfur cluster are not needed for this roleSaccharomyces cerevisiae
112I-AniI, Emericella nidulans (Aspergillus nidulans)mRNA maturase required for splicing of the intron in the cytochrome b (cobA) gene, which contains the coding sequence for the maturase. stimulates the intrinsic ribozyme activity of the intron by binding to and stabilizing the three-dimensional structure of the RNA. homing endonuclease introduces a double-strand break at a specific location in the cobA gene and helps in the insertion of an intron containing its own coding sequence (group I intron) Emericella nidulans (Aspergillus nidulans)
113Arg5,6, Saccharomyces cerevisiaeenzyme in the arginine biosynthetic pathway N-acetyl-gamma phosphate reductase and acetyl glutamate kinaseArg5 binds to mitochondrial and nuclear DNA in vivo and regulates gene expression, regulator of transcription for several genesSaccharomyces cerevisiae
114Argininosuccinate lyase, Anas platyrhynchos Argininosuccinate lyase, enzyme Catalyzes the breakdown of argininosuccinate to produce arginine and fumarate. It is the fourth enzyme of the urea cycle. Argininosuccinase is involved in biosythesis of arginine in all species and production of urea in ureotelic organisms. 2-(N(omega)-L-arginino)succinate => fumarate + L-arginine Amino-acid biosynthesis, arginine biosynthesisDelta-2 Crystallin in the lens of the eye - only in birds and reptilesAnas platyrhynchos (duck)
115lactate dehydrogenase, Anas platyrhynchoslactate dehydrogenase, enzyme lactate + NAD+ <=> pyruvate + NADH pyruvate fermentation to lactateStructural eye lens protein (epsilon-crystallin)- also in crocodile, hummingbird, chimney swiftAnas platyrhynchos (Mallard duck)
116retinol binding protein 1, Lygodactylus picturatusCellular retinol-binding protein Type 1 carrier protein involved in transport of retinol from liver to peripheral tissuescrystallin Ultraviolet Filter Lens protein Lygodactylus luteopicturatus (Yellow-headed Dwarf Gecko)
117 lactate dehydrogenase A, crystallin upsilon, Ornithorhynchus anatinus Lactate dehydrogenase A, enzyme Fermentation, Pyruvate fermentation to lactate pyruvate + NADH <=> lactate + NAD+ Catalyzes the conversion of pyruvate (final product of glycolysis) to lactateLens protein crystallinOrnithorhynchus anatinus (Duckbill platypus)
118Aldehyde dehydrogenase, Elephantus edwardiiretinaldehyde dehydrogenase, enzyme an aldehyde dehydrogenase class 1 An aldehyde + NAD+ + H2O => a carboxylate + NADH. Alcohol metabolism, ethanol degradationeta crystallin Elephantus edwardii (elephant shrew)
119L-gulonate 3-dehydrogenase, Lambda-crystallin, Oryctolagus cuniculusL-gulonate 3 -dehydrogenase, enzyme L-gulonate + NAD(+) <=> 3-dehydro-L-gulonate + NADH Catalysis the NAD-linked dehydrogenation of L-gulonate into dehydro-L-gulonate in the urinate cycle. Lambda crystallin Oryctolagus cuniculus (Rabbit)
120Quinone oxidoreductase, Zeta-crystallin, Cavia porcellusQuinone oxidoreductase NADPH:quinone oxidoreductase NADPH + 2 quinone <=> NADP(+) + 2 semiquinone Zeta-crystallin (Also in camels, llamas, and tree frog)Cavia porcellus (Guinea pig)
121NADPH quinone oxidoreductase, Zeta-crystallin, Hyla japonicaNADPH:quinone oxidoreductase, enzymeZeta crystallin (Also in camel, llamas and Guinea pig)Hyla japonica (Japanese tree frog)
122Carbinolamine dehydratase, Rattus norvegicusPterin-4-alpha-carbinolamine dehydratase, enzyme convert 4a-hydroxy tetrahydropterin to quinonoid dihydrobiopterin, in phenylalanine hydroxylation reaction (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin => (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2Odimerization of hepatocyte nuclear factor 1? (HNF1A), a homeodomain transcription factor, results in transcription activation Rattus norvegicus
123Lactose synthase, Homo sapiensLactose synthase, enzyme UDP-alpha-D-galactose + D-glucose <=> UDP + lactoseGalactosyltransferase, enzyme UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1Homo sapiens (Human)
124DegP, Escherichia colipeptidase at higher temperatures.chaperone at low temperatures Escherichia coli (strain K12)
125Albaflavenone Monooxygenase, Streptomyces coelicolorAlbaflavenone Monooxygenase (+)-epi-isozizaene + 2 NADPH + 2 O(2) <=> albaflavenone + 2 NADP(+) + 3 H(2)O Terpene synthase (2E,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphatestreptomyces coelicolor A3(2)
126Delta-aminolevulinic acid dehydratase, Homo sapiens5-aminolaevulinate dehydratase, enzyme converts 2 (5-aminolevulinate) to porphobilinogen +2H20. Porphyrin-containing compound metabolism, protoporphyrin-IX biosynthesisproteasome inhibitor Noncompetitively blocks proteolysis of certain protein substrates. Homo sapiens
127FtsH, Shigella flexnerichaperoneMetalloprotease, enzyme ATP-dependent zinc metallopeptidase, hydrolyzes cytoplasmic and transmembrane proteinsShigella flexneri
128Leukotriene A-4 hydrolase, Homo sapiensLeukotriene A-4 hydrolase, enzyme epoxide hydrolase (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O <=> (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate catalyzes the last step in the biosynthesis of leukotriene B4. Lipid metabolism, leukotriene B4 biosynthesisAminopeptidase, enzyme Homo sapiens (Human)
129Lysyl hydroxylase, Homo sapiensLysyl hydroxylase isoform 3, enzyme L-lysine-[procollagen] + 2-oxoglutarate + O(2) <=> (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO(2) Important for formation of intermolecular cross-links in collagen, helps provide strength to collagen acts at -Xaa-Lys-Gly- sequences Collagen glucosyltransferase UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagenHomo sapiens
130Phosphoglycerate Kinase, Homo sapiensPhosphoglycerate Kinase, enzyme ADP + 1,3-bisphosphoglycerate => ATP + 3-phospho-D-glycerate Carbohydrate degradation, glycolysisdisulphide reductase, enzyme Inhibits angiogenesis through a disulfide reductase activity that activates plasminogen autoproteolytic activity, producing angiostatin. One or more of the PGK cysteine residues may have a role in plasmin reduction. Homo sapiens (Human)
131Prostaglandin H2 Synthase, Ovis aries Prostaglandin H2 synthase-1, enzyme Arachidonate + AH(2) + 2 O(2) <=> prostaglandin H(2) + A + H(2)O Lipid metabolism, prostaglandin biosynthesisPeroxidase and cyclo-oxygenase 2 phenolic donor + H(2)O(2) <=> 2 phenoxyl radical of the donor + 2 H(2)OOvis aries (Sheep)
132Mismatch repair endonuclease PMS2, Mus musculusPMS2 mismatch repair enzyme introduces single-strand breaks near the mismatch Hypermutation of antibody variable chainsMus musculus
133Thymosin beta-4, Homo sapiensInvolved in sequestering G-actin (monomeric actin) in human polymorphonuclear leukocytes (PMNs). secreted anti-inflammatory agent Homo sapiens (Human)
134Ure2, Saccharomyces cerevisiaefunctions in nitrogen catabolite repression binds to and inhibits GATA transcriptional activators GLN3 and GAT1, keeps them in the cytoplasm, prevents transcription of their target genes glutathione peroxidase, enzyme also thiol:disulfide oxidoreductase 2 glutathione + H2O2 => glutathione disulfide + 2 H2OSaccharomyces cerevisiae
135Acetohydroxyacid isomerase, Saccharomyces cerevisiaeacetohydroxyacid reductoisomerase, enzyme Amino-acid biosynthesis, L-leucine, L-isoleucine and L-valine biosynthesis (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ => (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ => (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH Cofactor maintain mitochondrial DNA stability enzyme catalytic function not needed for this roleSaccharomyces cerevisiae
136PutA, Salmonella typhimuriumProline dehydrogenase / Proline oxidase pyrroline-5-carboxylic acid dehydrogenase activitytranscriptional repressor of the put operonSalmonella typhimurium
137GCN4 transcription factor, Saccharomyces cerevisiaetranscription factor; transcription activatorribonucleaseSaccharomyces cerevisiae
138birA biotin sythetase, Escherichia colibirA biotin synthetase, enzyme biotin--[acetyl-CoA-carboxylase] ligase ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]. bio operon repressor repressor activity depends on cellular concentration of biotinEscherichia coli
139Clf1p pre-mRNA splicing factor, Saccharomyces cerevisiaeClf1p pre-mRNA splicing factor involved in assembly of spliceosome Initiation of DNA replication binds to origin of replication complex Saccharomyces cerevisiae
140Thymidine phosphorylase, Homo sapiensThymidine phosphorylase thymidine + phosphate <=> thymine + 2-deoxy-alpha-D-ribose 1-phosphate Pyrimidine metabolism, dTMP biosynthesis in salvage pathwayPlatelet-derived endothelial cell growth factor Homo sapiens
143Citrate synthase, Tetrahymena thermophilacitrate synthase, enzyme acetyl-CoA + oxaloacetate + H2O => citrate + CoA-SH Citric acid cycle14-nm cytoskeletal proteinTetrahymena thermophila
144Galactokinase, Kluyveromyces lactisgalactokinase ATP + galactose => ADP + galactose 1-phosphate. Carbohydrate metabolism; galactose metabolismtranscriptional activator of GAL genes Kluyveromyces lactis
145Glutamate racemase, Mycobacterium tuberculosisglutamate racemase L-glutamate <=> D-glutamate Cell wall biogenesis, peptidoglycan biosynthesisDNA gyrase relieves strain when double-stranded DNA is being unwound Mycobacterium tuberculosis
146Hemagglutinin, Paramyxovirushemagglutinin binding the virus to the surface of host cells Neuraminidase, enzyme cleaves the glycosidic linkages of neuraminic acidsParamyxovirus (Mumps virus)
147Transketolase, Escherichi colitransketolase, enzyme Pentose Phosphate Pathway Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-ribose 5-phosphate + D-xylulose 5-phosphate. Transcriptional regulator derepresses the marRAB multiple antibiotic resistance operon by binding to the MarR repressor a "trigger enzyme"Escherichia coli
148Tyrosyl tRNA synthetase, Neurospora crassa tyrosyl tRNA synthetase, enzyme attaches tyrosine to tRNA(Tyr) ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)promotes folding of group 1 intronsNeurospora crassa
149Ag85A, Mycobacterium tuberculosismycolyltransferase, enzyme cell wall assembly Transesterification of mycolic acidsfibronectin-bindingMycobacterium tuberculosis
150Aconitase, Bos taurusaconitase, enzyme 4Fe-4S cluster in active site when cellular iron levels are high Citrate <=> isocitrate Citric acid cycleiron responsive element binding protein when cellular iron concentrations are low, loses 4Fe-4S cluster and binds to iron-responsive elements (IRES) in mRNA that encodes proteins that are involved in iron uptake and use Bos taurus (bovine)
151Folate receptor, Mus musculusfolate receptor binds folate and derivatives and brings them into the cell during endocytosis transcription factor Mus musculus
152Dihydroxyacetone kinase, Escherichia colidihydroxyacetone kinase, enzyme ATP + glycerone <=> ADP + glycerone phosphate (glycerone also called dihydroxyacetone)controls gene expression by binding to transcription factor DhaR, a trigger enzymeEscherichia coli
153Aaa autolysin, Staphylococcus aureusAaa autolysin peptidoglycan hydrolase, enzyme in cell division, cell separation, and cell wall turnover also bacteriolytic activity cleaves some cell wall glycopeptides, hydrolyzes the link between L-amino acid residues and N-acetylmuramoyl residues fibronectin binding, adhesinStaphylococcus aureus
154Aae autolysin, Staphylococcus epidermidisAae autolysin peptidoglycan hydrolase in cell-wall turnover and cell division bacteriolytic activity binds fibrinogen, fibronectin and vitronectinStaphylococcus epidermis
155AtlC, Staphylococcus capraeautolysin, enzyme N-acetylmuramoyl-L-alanine amidase hydrolyze peptidoglycan in cell wallfibronectin bindingStaphylococcus caprae
156Ami autolysin, Listeria monocytogenesautolysin, enzyme cleaves cell wall glycopeptides, at the link between the L-amino acid residues and the N-acetylmuramoyl residues adherence to eukaryotic cellsListeria monocytogenes
157Ag85B, Mycobacterium tuberculosismycolyltransferase, enzyme cell wall assembly Transesterification of mycolic acidsfibronectin bindingMycobacterium tuberculosis
158Ag85C, Mycobacterium tuberculosismycolyltransferase, enzyme cell wall assembly Transesterification of mycolic acidsfibronectin bindingMycobacterium tuberculosis
159Thioredoxin, Escherichia colithioredoxin antioxidant aids the reduction of other proteins by cysteine thiol-disulfide exchangeSubunit of T7 DNA polymerase ****maybe not strictly considered moonlighting because adopted by a phage to be part of a protein complex*****Escherichia coli
160Lymphotactin, Homo sapienscytokine agonist for XCR1, the specific G-protein-coupled receptor for lymphotactinbinding to cell-surface glycosaminoglycans **a Metamorphic protein - different fold than when cytokine***Homo sapiens
161ATF2, Homo sapiensATF2 activating transcription factor bZIP family of transcription factors binds DNA as a dimer, homodimerization or heterodimerization, sometimes with c-Jun recruiting Mre11 to IR-induced foci (IRIF) in the DNA damage response, this function does not require DNA binding domain or dimerization with c-JunHomo sapiens
162ATF2, Mus musculusATF2 activating transcription factor bZIP family of transcription factors binds DNA as a dimer, homodimerization or heterodimerization, sometimes with c-Jun recruiting Mre11 to IR-induced foci (IRIF) in the DNA damage response, this function does not require DNA binding domain or dimerization with c-Jun Mus musculus
163Glutamine synthetase, Bacillus subtilis glutamine synthetase catalyzes the synthesis of glutamine from glutamate and ammonia ATP + L-glutamate + NH3 => ADP + phosphate + L-glutaminebinds to transcription factor TnrA, a global regulator of transcription, and prevents it from binding to DNABacillus subtilis
164Glutamate dehydrogenase, Bacillus subtilisglutamate dehydrogenase deaminates glutamate to form ?-ketoglutarate L-glutamate + H2O + NAD+ => 2-oxoglutarate + NH3 + NADH.interacts directly with GltC, a LysR-type transcription factorBacillus subtilis
165High mobility group protein B1, Rattus norvegicus binds heparin involved in extension of neurite-type cytoplasmic processes DNA binding protein, without sequence specificity associates with chromatin, may play structural role bends DNA Rattus norvegicus (Rat)
166Arg82, Saccharomyces cerevisiaekinase, enzyme phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate => 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate. stabilizes transcription factors ARG80 and MCM1 Saccharomyces cerevisiae
167Arginase, Saccharomyces cerevisiaearginase use of arginine as nitrogen source L-arginine + H2O => L-ornithine + urea Nitrogen metabolism, urea cyclebinds to ornithine transcarbamylase and inactivates it (OTCase, catalyzes first step in arginine biosynthesis), effectors are ornithine and arginine Saccharomyces cerevisiae
168Epimorphin, Syntaxin-2, Homo sapiensepimorphin - mediates epithelial tissue morphogenesis outside the cell syntaxin 2 controls protein secretion from endoplasmic reticulumGolgi-derived vesicles it is a target SNARE (t-SNARE) on the cytoplasmic side of the plasma membranes that aids in fusion of the plasma membrane with vesicles that carry the appropriate vesicle SNARE (v-SNARE) proteinsHomo sapiens
169Calreticulin, Homo sapienschaperone promotes protein folding and assembly of oligomers involved in protein quality control adhesin Homo sapiens
170Erk2, Homo sapiensErk2 kinase, enzyme Serine/threonine kinase ATP + a protein => ADP + a phosphoprotein.transcriptional repressor represses expression of interferon gamma-induced genesHomo sapiens
171L13a, Homo sapienribosome protein, part of 60S subunit of ribosome translation inhibition Component of the GAIT complex (gamma interferon-activated inhibitor of translation) Homo sapien
172Glutamyl-prolyl tRNA synthetase, Homo sapiensglutamyl-prolyl tRNA synthetase, enzyme an aminoacyl-tRNA synthetase catalyze the attachment of amino acids to cognate tRNAs ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Glu) ATP + L-proline + tRNA(Pro) => AMP + diphosphate + L-prolyl-tRNA(Pro)translation inhibition part of GAIT complex: interferon (IFN)-gamma-activated inhibitor of translation silences ceruloplasmin mRNA translation Homo sapiens
173Glyceraldehyde-3-phosphate dehydrogenase, Homo sapiensglyceraldehyde-3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ => 1,3-bis-phosphogycerate + NADH Carbohydrate degradation, glycolysistranslation inhibition part of GAIT complex: interferon (IFN)-gamma-activated inhibitor of translation that silences ceruloplasmin mRNA translation Homo sapiens
174L7 ribosomal, Methanococcus jannaschiipart of the ribosomesRNP core protein binds the box C/D snoRNA core motif, homologue of eukaryotic 15.5kD proteinMethanococcus jannaschii
175RACK1, Saccharomyces cerevisiaeComponent of the 40S (small) ribosomal subunitscaffold in cytoplasmic signal transduction pathwaysSaccharomyces cerevisiae
177L10 ribosomal protein, Homo sapiensComponent of the large subunit (60S) of the ribosome negative regulator of c-Jun in transcriptionHomo sapiens
178L32, Saccharomyces cerevisiaeComponent of the ribosome large subunit (60S)inhibits the splicing of the transcript of its own gene, RPL32Saccharomyces cerevisiae
179S14 ribosomal protein, Saccharomyces cerevisiaeComponent of the ribosome small subunit (40S)represses expression of RPS14B gene rpS14 binds directly to RNA, binds to an RNA stem-loop structure in RPS14B pre-mRNA Saccharomyces cerevisiae
180L2 ribosomal protein, Saccharomyces cerevisiaeComponent of the ribosome large subunit (60S). regulates accumulation of L2 mRNA, shortens half-life of L2 mRNA Saccharomyces cerevisiae
181S28 Ribosomal protein, Saccharomyces cerevisiaeComponent of the ribosome small subunit (40S)shortens half-life of own mRNA binds to hairpin structure in 3' UTR and also to the decapping machinerySaccharomyces cerevisiae
182L12 ribosomal protein, Caenorhabditis elegansribosomal protein Binds RNA directly (26S rRNA)inhibits splicing of its own RNACaenorhabditis elegans
183S13 ribosomal protein, Homo sapiensribosomal protein, part of the ribosomeinhibits splicing of own RNA transcript inhibit removal of intron 1 from rpS13 pre-mRNA Homo sapiens
184L11 ribosomal protein, Mus musculusribosomal protein, part of 60S subunitBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor proteinMus musculus
185L11 ribosomal protein, Homo sapiensribosomal protein, part of 60S subunitBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor proteinHomo sapiens
186L5 ribosomal protein, Homo sapiensribosomal protein, part of the 60S subunitBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of the p53 tumor suppressor proteinHomo sapiens
187S7 ribosomal protein, Homo sapiensribosomal protein, part of 40S subunitBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of the p53 tumor suppressor proteinHomo sapiens
188L26 ribosomal protein, Homo sapiensribosomal protein, part of 60S subunitregulates (increases) translation of p53 tumor suppressor protein after DNA damage, leading to cell cycle arrest and apoptosis binds 5' UTR of p53 mRNAHomo sapiens
189Nucleolin, Homo sapienssynthesis and maturation of ribosomesregulates (decreases) translation of p53 tumor suppressor protein binds 5' UTR of p53 mRNAHomo sapiens
190L23 ribosomal protein, Homo sapiensribosomal protein, part of 60S subunitBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor protein Homo sapiens
191L10 ribosomal protein, Arabidopsis thalianaribosomal protein, part of 40S subunit Involved in NSP-interacting kinase (NIK) receptor-mediated defense pathway to defend against geminivirus substrate and binding partner of NIK1 Arabidopsis thaliana
192S3 ribosomal protein, Drosophila melanogasterribosomal protein, part of 40S subunitDNA repair activity cleaves DNA at apurinic/apyrimidinic sites Drosophila melanogaster
193EF-G, Streptococcus gordoniielongation factor in translation catalyzes translocation step, uses GTPadhesin, binds salivary mucin MUC7Streptococcus gordonii
194L4 ribosomal protein, Escherichia coliribosomal protein, part of the 50S subunittranscriptional repressor causes premature termination of transcription within S10 operonEscherichia coli
195Enolase, Streptococcus gordoniienolase, enzyme Catalyzes the interconversion of 2-phosphoglycerate and phosphoenolpyruvate 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysisadhesin, binds salivary mucin MUC7Streptococcus gordonii
196Fructose-1,6-bisphosphate aldolase/phosphatase, Sulfolobus tokodaiifructose-1,6-bisphosphatase, enzyme dephosphorylation of FBP to fructose-6-phosphate fructose-1,6-bisphosphate aldolase, enzyme reversible aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to FBPSulfolobus tokodaii
197Fructose-1,6-bisphosphate aldolase/phosphatase, Thermoproteus neutrophilusfructose-1,6-bisphosphatase, enzyme dephosphorylation of FBP to fructose-6-phosphate fructose-1,6-bisphosphate aldolase, enzyme reversible aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to FBPThermoproteus neutrophilus
198DegQ, Escherichia colipeptidase, enzyme chaperone, aids in folding of proteins Escherichia coli
199Cdt1, Homo sapienshelps load proteins onto chromatin to create the pre-replication complex for initiating DNA replication role in mitosis localizes to kinetochores through binding to the Hec1 component of the Ndc80 complex Homo sapiens
200MalY, Escherichia colibeta-cystathionase, enzyme cleavage of cystathionine to homocysteine, ammonia, and pyruvate L-cystathionine + H2O => L-homocysteine + NH3 + pyruvate Amino-acid biosynthesis, methionine biosynthesis transcription regulation binds to MalT activator of mal regulon and prevents its actionEscherichia coli
201Hexokinase, Saccharomyces cerevisiaehexokinase, enzyme ATP + D-hexose => ADP + D-hexose 6-phosphate. Carbohydrate metabolism, hexose metabolism, glycolysisHxk2 interacts directly with Mig1, a transcriptional repressor that binds to promoters of genes that are repressed by glucose high glucose causes Hxk2 to move to the nucleusSaccharomyces cerevisiae
202GmaR, Listeria monocytogenesO-GlcNAc transferase glycosyltransferase that mediates beta-O-linked GlcNAc modification of flagellin (FlaA)transcriptional regulator anti-repressor, target is MogR (a transcriptional repressor), binds to MogR and prevents it from binding to DNAListeria monocytogenes
203Pyruvate carboxylase, Hansenula poymorphaPyruvate carboxylase, enzyme ATP + pyruvate + HCO3- => ADP + phosphate + oxaloacetate. Carbohydrate biosynthesis, gluconeogenesis assembly of peroxisomal alcohol oxidase (AOX) may mediate FAD binding to AOX monomers in cytoplasm, which enables them to be transported to the peroxisome where they can assemble into the active octomeric formHansenula poymorpha (Pichia angusta) (Yeast)
204PyrH, Escherichia coliUMP kinase, enzyme phosphorylates UMP to UDP ATP + UMP <=> ADP + UDP de novo biosynthetic pathway of pyrimidine nucleotidestranscriptional regulator involved in pyrimidine-specific repression of the carAB operon binds to PepA Escherichia coli
205CysK, Bacillus subtilisCysteine synthase, enzyme O-acetyl-serine + H2S = cysteine + acetate Amino-acid biosynthesis, biosynthesis of cysteinetranscriptional regulator regulates activity of CymR transcription factor forms complex with CymR that represses transcription of the CymR regulon Bacillus subtilis
206Aes, Escherichia coliesterase, enzyme esterase of short chain fatty esters with up to 8 carbons in acyl chaintranscription regulation binds to MalT activator of mal regulon and prevents its actionEscherichia coli
207PutA, Escherichia coliProline dehydrogenase / Proline oxidase, enzyme L-proline + a quinone => (S)-1-pyrroline-5-carboxylate + a quinol L-glutamate 5-semialdehyde + NAD+ + H2O => L-glutamate + NADH Amino-acid degradation, L-proline degradation into L-glutamatetranscriptional repressor of the put operon Escherichia coli
208NadR, Escherichia colinicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase activities, enzyme ATP + nicotinamide ribonucleotide => diphosphate + NAD+ ATP + 1-(beta-D-ribofuranosyl)-nicotinamide => ADP + beta-nicotinamide D-ribonucleotide NAD biosynthesisTranscriptional repressor binds to the nadB operator DNA sequence Increasing NAD causes an increase in the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB Escherichia coli
209PepA, Escherichia coliaminopeptidase, enzyme removes amino-terminal amino acid, preferentially if it is Leu transcriptional repressor binds DNA, binds car operator DNA represses the carAB operon Escherichia coli
210Glucose permease, Escherichia coliphosphorylates glucose, enzyme sugars are phosphorylated during transport through the channel subunit of the protein complex IIB subunit binds and sequesters Mlc transcription repressor in presence of glucoseEscherichia coli
211MalK, Escherichia coliATP binding/hydrolysis protein of MalEFGK maltose/maltodextrin transporter (importer) an ABC transporter ATP + H2O = ADP + phosphate transcription regulation binds to MalT activator of mal regulon and prevents its actionEscherichia coli
212DhaK, Escherichia colisubunit of dihydroxyacetone kinase, enzyme phosphorylates dihydroxyacetone contains the Dha binding site corepressor of DhaR transcription activator binds to DhaR affects transcription of the dhaKLM operon Escherichia coli
213DhaL, Escherichia colisubunit of dihydroxyacetone kinase, enzyme phosphorylates dihydroxyacetone contains the ADP-binding site coactivator of DhaR transcription activator binds to DhaR affects transcription of the dhaKLM operon Escherichia coli
215Formiminotransferase, Thermoplasma acidophilumformiminotransferase, enzyme histidine breakdown5-formyltetrahydrofolate cycloligase ATP + 5-formyltetrahydrofolate <=> ADP + phosphate + 5,10-methenyltetrahydrofolateThermoplasma acidophilum
216Sarcosine oxidase alpha subunit, Thermococcus kodakarensisSarcosine oxidase, enzyme oxidation of the methyl group in sarcosine and transfer to folate oxidative demethylation of sarcosine to yield glycine and 5,10-CH2-tetrahydrofolate NADH dehydrogenase NADH + H+ + acceptor <=> NAD+ + reduced acceptor Thermococcus kodakarensis
217Sarcosine oxidase beta subunit, Thermococcus kodakarensisSarcosine oxidase, enzyme oxidation of the methyl group in sarcosine and transfer to folate oxidative demethylation of sarcosine to yield glycine and 5,10-CH2-tetrahydrofolate L-proline dehydrogenase, enzyme L-proline + acceptor <=> (S)-1-pyrroline-5-carboxylate + reduced acceptor Thermococcus kodakarensis
218TreX, Sulfologus solfataricusalpha-1,4-transferase, enzyme alpha-1,6-glucosidase, enzymeSulfologus solfataricus
219Thymidylate synthase, Homo sapiensthymidylate synthase, enzyme de novo synthesis of thymidylate, a DNA precursor 5,10-methylenetetrahydrofolate + dUMP <=> dihydrofolate + dTMP Pyrimidine metabolism, dTTP biosynthesismRNA translation inhibition regulation of human TS mRNA translation does not bind to unrelated mRNAs Homo sapiens
220Thymidylate synthase, Plasmodium falciparumDihydrofolate reductase and Thymidylate synthase, enzyme 5,6,7,8-tetrahydrofolate + NADP+ <=> 7,8-dihydrofolate + NADPH 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP Tetrahydrofolate biosynthesismRNA translation inhibition regulation of plasmodium TS-DHFR mRNA translation Plasmodium falciparum
222Dihydrofolate reductase, Homo sapiensdihydrofolate reductase, enzyme 5,6,7,8-tetrahydrofolate + NADP+ => 7,8-dihydrofolate + NADPH tetrahydrofolate biosynthesisbinds DHFR mRNA regulation of DHFR synthesis methotrexate inhibits interaction Homo sapiens
223Serine hydroxymethyltransferase, Homo sapiensserine hydroxymethyltransferase, enzyme 5,10-methylenetetrahydrofolate + glycine + H2O <=> tetrahydrofolate + L-serine One-carbon metabolism, tetrahydrofolate interconversionbinds mRNA binds the 5' untranslated region (UTR) of its own mRNA Homo sapiens
224Uracil phosphoribosyltransferase, Bacillus caldolyticusuracil phosphoribosyltransferase, enzyme UMP + diphosphate <=> uracil + 5-phospho-alpha-D-ribose 1-diphosphate binds mRNA transcriptional attenuation of the pyrimidine nucleotide biosynthetic (pyr) operon binds upstream of the genes being regulated Bacillus caldolyticus
225Creatine kinase, Rattus norvegicuscreatine kinase, enzyme transfers phosphoryl group between ATP and various phosphogens (e.g. creatine phosphate) ATP + creatine <=> ADP + phosphocreatinebinds mRNA translation regulator binds 3' untranslated region (3' UTR) of mRNA of alpha myosin heavy chain (alphaMyHC) Rattus norvegicus
226Mevalonate kinase, Rattus norvegicusMevalonate kinase, enzyme ATP + (R)-mevalonate => ADP + (R)-5-phosphomevalonate Isoprenoid biosynthesis, mevalonate pathwaymRNA binding cytosolic luteinizing hormone receptor mRNA binding protein increases LH receptor mRNA degradation Rattus norvegicus
227Threonyl-tRNA synthetase, Escherichia coliThreonine-tRNA ligase, enzyme ATP + L-threonine + tRNA(Thr) => AMP + diphosphate + L-threonyl-tRNA(Thr)binds mRNA binds mRNA encoding threonyl-tRNA synthetase, controls expression of its own gene at the translational level Escherichia coli
229Enolase, Mycoplasma fermentansenolase, enzyme 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysisplasminogen binding Mycoplasma fermentans
230GroEL1, Mycobacterium tuberculosisprotein chaperone prevents proteins from misfolding, promotes correct refolding and assembly of polypeptidesbinds DNA low specificity but high affinity nucleoid-associated protein condenses DNA into a compact structure Mycobacterium tuberculosis
231Gephryn, Homo sapiensconnects membrane proteins to cytoskeleton microtubule binding protein anchors transmembrane receptors needed for clustering of inhibitory glycine receptors in postsynaptic membranes in the rat central nervous system Molybdopterin adenylyltransferase and Molybdopterin molybdenumtransferase, enzyme biosynthesis of the molybdenum cofactor catalyzes two steps ATP + molybdopterin => diphosphate + adenylyl-molybdopterin. Adenylyl-molybdopterin + molybdate => molybdenum cofactor + AMP. Cofactor biosynthesis, molybdopterin biosynthesis Homo sapiens
232Cytochrome C, Equus caballusElectron carrier protein component of the mitochondrial electron-transport chain binding to apoptosis protease activation factor-1 (Apaf-1) promotes apoptosis release from mitochondria allows interaction with apoptosis proteins Equus caballus (Horse)
233Cytochrome C, Saccharomyces cerevisiaeElectron carrier protein component of the mitochondrial electron-transport chain binding to apoptosis protease activation factor-1 (Apaf-1) promotes apoptosis release from mitochondria allows interaction with apoptosis proteins Saccharomyces cerevisiae
234Aconitase, Homo sapiensaconitase, enzyme 4Fe-4S cluster in active site when cellular iron levels are high Citrate <=> isocitrate Citric acid cycleiron responsive element binding protein when cellular iron concentrations are low, loses 4Fe-4S cluster and binds to iron-responsive elements (IRES) in mRNA that encodes proteins that are involved in iron uptake and use Homo sapiens
235Alaninyl-tRNA syntetase, Escherichia coliAlanyl-tRNA synthetase, enzyme attaches alanine to tRNA(Ala) ATP + L-alanine + tRNA(Ala) => AMP + diphosphate + L-alanyl-tRNA(Ala)transcription regulator represses transcription of its own gene increased repression with increased alanine concentrations binds DNA Escherichia coli
236Leucyl-tRNA synthetase, Saccharomyces cerevisiaeLeucyl-tRNA synthetase, enzyme ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu) protein synthesisintron splicing, RNA splicing group I intron splicing Saccharomyces cerevisiae
237Leucyl-tRNA synthetase, Homo sapiensLeucyl-tRNA synthetase, enzyme attaches leucine to its cognate tRNA ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu) protein synthesis GTPase-activating protein (GAP) senses intracellular leucing concentration and binds to Rag GTPase Rag signals to mTORC1 promotes translocation of mTORC1 to the lysosomal membraneHomo sapiens
238Glutaminyl-tRNA synthetase, Homo sapiensGlutaminyl-tRNA synthetase, enzyme ATP + L-glutamine + tRNA(Gln) => AMP + diphosphate + L-glutaminyl-tRNA(Gln) protein synthesis interacts with ASK1 (Fas ligation activated apoptosis signal-regulating kinase 1) to inhibit apoptosis induced by ASK1 protein-protein interaction increased under conditions of increased glutamine concentration Homo sapiens
239Lysyl-tRNA synthetase, Rattus norvegicusLysyl-tRNA synthetase, enzyme ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys) protein synthesissynthesis of diadenosine tetraphosphate (diadenosine-5',5'''-P1,P4-tetraphosphate, Ap(4)A, AppppA) Ap4A then regulates transcription of MITF target genes Rattus norvegicus
240Tryptophanyl-tRNA synthetase, Homo sapiensTryptophanyl-tRNA synthetase, enzyme ATP + L-tryptophan + tRNA(Trp) => AMP + diphosphate + L-tryptophyl-tRNA(Trp) protein synthesisforms complex with the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and poly(ADP-ribose) polymerase 1 (PARP-1) the complex activates p53 Homo sapiens
241MSCp43, Mus musculusscaffold protein in the multisynthase complex forms a multi-protein complex with glutamyl-, prolyl-, isoelucyl-, leucyl-, methionyl-, glutaminyl-, lysyl-, arginyl-, and aspartyl-tRNA synthetases, AIMP2/p38, and AIMP3/p18cytokine roles in angiogenesis - inducing endothelial cell migration induces maturation of dendritic cells induces monocyte cell adhesion Mus musculus
242MSCp38, Mus musculusscaffold protein in the multisynthase complex forms a multi-protein complex with glutamyl-, prolyl-, isoelucyl-, leucyl-, methionyl-, glutaminyl-, lysyl-, arginyl-, and aspartyl-tRNA synthetases, AIMP1/p24, and AIMP3/p18binds to FUSE-binding protein (FBP), a transcriptional activator of c-myc the protein-protein interaction causes an increase in the ubiquitination and degradation of FBP, which results in downregulation of c-myc differentiation of lung cells Mus musculus
243MSCp18, Mus musculusscaffold protein in the multisynthase complex forms a multi-protein complex with glutamyl-, prolyl-, isoelucyl-, leucyl-, methionyl-, glutaminyl-, lysyl-, arginyl-, and aspartyl-tRNA synthetases, AIMP2/p38, and AIMP3/p24protein-protein interaction with ATM/ATR that results in p53 activation translocates to nucleus and plays a role in DNA repair Mus musculus
244Lysyl-tRNA synthetase, Homo sapiensLysyl-tRNA synthetase, enzyme ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys) protein synthesis cytokine binds to macrophages and peripheral blood mononuclear cells increases TNF-alpha production by target cells increases target cell migration Homo sapiens
245Methionyl-tRNA synthetase, Homo sapiensMethionyl-tRNA synthetase, enzyme ATP + L-methionine + tRNA(Met) => AMP + diphosphate + L-methionyl-tRNA(Met) protein synthesisbiogenesis of rRNA in nucleoli translocation to nucleolus triggered by growth factors Homo sapiens
246L1 ribosomal protein, Escherichia coliribosomal protein, part of the 50S subunit translational repressor binds to the mRNA of the L11 operon Escherichia coli
247S4 ribosomal protein, Escherichia coliS4 ribosomal protein part of the 30S subunit, helps nucleate assembly of the 30S subunit by binding directly to the 16S rRNA translational repressor binds mRNA of operon encoding S3, S11, S4Escherichia coli
248S8 ribosomal protein, Escherichia coliS8 ribosomal protein part of the 30S subunit binds to 16S rRNA translational repressor inhibits expression of some proteins encoded by the spc operon Escherichia coli
249Argonaute4, Arabidopsis thalianaComponent of the RISC complex RNA-directed DNA methylation, involves small interfering RNA (siRNA) RNA-directed gene silencing cleaves RNA transcripts, enzyme generates small interfering RNAs (siRNAs) Arabidopsis thaliana
250Ubp6, Saccharomyces cerevisiaedeubiquitinase, enzyme associated with proteasome releases ubiquitin from ubiquitinated proteins that bind to the proteasome inhibits proteasome activity delays the degradation of ubiquitinated proteins by the proteasome enables gradual deubiquitination of the substrate Saccharomyces cerevisiae
251hRoDH-E2, Homo sapiensretinol dehydrogenase, enzyme all-trans-retinol + NAD+ <=> all-trans-retinal + NADH. Cofactor metabolism, retinol metabolism transcriptional repressor represses profilaggrin promoter activity by adjusting the activity of Sp1 and other activators Homo sapiens
252Pyruvate kinase, Rattus norvegicusPyruvate kinase, enzyme ATP + pyruvate => ADP + phosphoenolpyruvate Carbohydrate degradation, glycolysis enzyme as tetramerthyroid hormone binding activity monomer binds 3,3',5-triiodo-L-thyronine (T3) Rattus norvegicus
253Sulfite reductase, Pisum sativumSulfite reductase, enzyme Hydrogen sulfide + 6 oxidized ferredoxin + 3 H2O <=> sulfite + 6 reduced ferredoxin + 6 H+ compact DNA in nucleoids of plastids method to regulate transcription Pisum sativum (garden pea)
254Band 3 anion exchanger, Homo sapiensBand 3 anion exchanger transports inorganic anions across the plasma membrane in a 1:1 exchange scaffold protein providing binding sites for glycolytic enzymes involved in regulation of catalytic activity of glycolytic enzymes site of binding is N-terminal cytoplasmic domain of Band 3Homo sapiens
255Hal3, Saccharomyces cerevisiaeSubunit of phosphopantothenoylcysteine decarboxylase (PPCDC) coenzyme A biosynthesis pathway inhibitory subunit of protein phosphatase PPZ1 Saccharomyces cerevisiae
256Vhs3, Saccharomyces cerevisiaeSubunit of phosphopantothenoylcysteine decarboxylase (PPCDC) coenzyme A biosynthesis pathway inhibitory subunit of protein phosphatase PPZ1 Saccharomyces cerevisiae
257I-Tev1 endonuclease, bacteriophage T4homing endonuclease, enzyme intron-encoded binds cognate intronless alleles transcriptional autorepressor bacteriophage T4
258Pth2/Bit1, Homo sapiensPeptidyl-tRNA hydrolase, enzyme aminoacyl-tRNA + H2O => amino acid + tRNA releases tRNA from the premature translation termination product inhibitor of transcription protein-protein interactionHomo sapiens
259CFTR, Homo sapienschloride transporter ATP + H2O => ADP + phosphate contains nucleotide binding domains that bind and hydrolyze ATPregulator of other ion channelsHomo sapiens
260MDR1, Homo sapienstransmembrane transporter efflux pump, uses ATP for energy expels drugs and other small molecule compounds ATP + H2O + xenobiotic(Inside) => ADP + phosphate + xenobiotic(Outside)regulator of volume-activated chloride channels Homo sapiens
261Atla autolysin, Streptococcus mutansautolysin, enzyme cleaves cell wall peptidoglycanbinds fibronectinStreptococcus mutans
262Peroxiredoxin 1, Saccharomyces cerevisiaeperoxiredoxin peroxidase antioxidant 2 R'-SH + ROOH => R'-S-S-R' + H2O + ROH. molecular chaperones helps proteins foldSaccharomyces cerevisiae
263Peroxiredoxin 2, Saccharomyces cerevisiaeperoxiredoxin peroxidase antioxidant 2 R'-SH + ROOH => R'-S-S-R' + H2O + ROHmolecular chaperones helps proteins foldSaccharomyces cerevisiae
265Vps25, Drosophila melanogasterComponent of the ESCRT-II complex (ensodomal sorting complex required for transport II) complex needed for sorting ubiquitinated endosomal proteins into multivesicular bodies important for transport of transmembrane proteins to the lysosome for degradation with other members of the ESCRT complex, binds to the localization element in the 3' untranslated region (UTR) of bicoid mRNA functions in localizing bicoid mRNA to the anterior of the Drosophila egg Drosophila melanogaster
266Vps22, Drosophila melanogasterComponent of the ESCRT-II complex (ensodomal sorting complex required for transport II) complex needed for sorting ubiquitinated endosomal proteins into multivesicular bodies important for transport of transmembrane proteins to the lysosome for degradationwith other members of the ESCRT complex, binds to the localization element in the 3' untranslated region (UTR) of bicoid mRNA functions in localizing bicoid mRNA to the anterior of the Drosophila egg Drosophila melanogaster
267Vps36, Drosphila melanogasterComponent of the ESCRT-II complex (ensodomal sorting complex required for transport II) complex needed for sorting ubiquitinated endosomal proteins into multivesicular bodies important for transport of transmembrane proteins to the lysosome for degradation mRNA binding binds to the localization element in the 3' untranslated region (UTR) of bicoid mRNA functions in localizing bicoid mRNA to the anterior of the Drosophila egg Drosphila melanogaster
268Aspartate receptor, Escherichia coliaspartate receptor binds aspartate transmembrane receptor for aspartatebinds maltose binding protein maltose receptor transmembrane receptor for maltose binding protein Escherichia coli
269L14 ribosomal protein, Escherichia coliribosomal protein part of the 30S subunit binds to the 23S rRNA binds DNA stimulates unwinding of DNA by Rep helicase protein Escherichia coli
270S14 ribosomal protein, Homo sapiensribosomal protein inhibits S14 mRNA transcription negative effector of transcription of its own RNA Homo sapiens
271STAT3, Mus musculustranscription factor, binds DNA in response to cytokines (IL-6, and other growth factors) binds promoters containing IL-6 responsive elements modulates the activities of complexes I and II of the electron transport chain (ETC) in the mitochondriaMus musculus
273Fructose-bisphosphate aldolase, Plasmodium bergheiFructose-bisphosphate aldolase, enzyme D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate Carbohydrate degradation, glycolysisattaches actin filaments to TRAP proteins (transmembrane adhesive proteins of the thrombospondin-related anonymous protein) and transduces the motor force across the surface of the plasmodium Plasmodium berghei
274Fructose-bisphosphate aldolase, Toxoplasma gondiiFructose-bisphosphate aldolase, enzyme D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate Carbohydrate degradation, glycolysisprotein-protein interactions couples actin cytoskeleton filaments in the cytoplasm to the surface adhesin microneme protein 2 (MIC2)Toxoplasma gondii
275Gpx4, Homo sapiensPhospholipid hydroperoxide glutathione peroxidase, enzyme removes membrane lipid peroxidation, cell protection 2 glutathione + a lipid hydroperoxide => glutathione disulfide + lipid + 2 H2Ostructural role in capsule in mature spermatozoa Homo sapiens
276Lactose synthetase, Bos taurusLactose synthetase, enzyme UDP-alpha-D-galactose + D-glucose => UDP + lactose UDP-galactose: N-acetylglucosamine galactosyltransferase, enzyme UDP-alpha-D-galactose + N-acetyl-D-glucosamine => UDP + N-acetyllactosamineBos taurus
277Isocitrate dehydrogenase 1, Saccharomyces cerevisiaeIsocitrate dehydrogenase, enzyme Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH Citric acid cyclebinds mRNA binds specifically to 5'-untranslated leaders of mitochondrial mRNAs Saccharomyces cerevisiae
278Isocitrate dehydrogenase 2, Saccharomyces cerevisiaeIsocitrate dehydrogenase, enzyme Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH Citric acid cyclebinds mRNA binds specifically to 5'-untranslated leaders of mitochondrial mRNAs Saccharomyces cerevisiae
279Germin, Hordeum vulgareOxalate oxidase, enzyme Oxalate + O2 + 2 H+ => 2 CO2 + H2O2superoxide dismutase, enzyme 2 superoxide (O2-) + 2 H(+) <=> O(2) + H(2)O(2)Hordeum vulgare
280S10 ribosomal protein, Escherichia coliribosomal protein part of the 30S subunitpart of an antitermination apparatus antitermination of Rho-dependent and Rho-independent terminators Escherichia coli
282P0 ribosomal protein, Drosophila melanogasterP0 ribosomal protein part of the 60S subunitApurinic-apyrimidinic endonuclease, enzyme functions in DNA repair act on AP DNA, cleaves 5' of a baseless site Drosophila melanogaster
283L10 ribosomal protein, Escherichia coliribosomal protein part of the 50S subunit translation inhibitor autogenous regulation of translation Escherichia coli
284S7 ribosomal protein, Escherichia coliribosomal protein binds to 16S rRNA part of the 30S subunittranslational repressor regulates the expression of two proteins encoded by the str operon Escherichia coli
286Matrix metaloproteinase 12, Mus musculusMatrix metaloproteinase, enzyme cleaves elastin, IFN-?promotes transcription binds to the NFKBIA promoter Mus musculus
287dCTP deaminase, Methanocaldococcus jannaschiidCTP deaminase deamination of the cytosine moiety in dCTP dCTP + 2 H2O => dUMP + diphosphate + NH3 Pyrimidine metabolism, dUMP biosynthesishydrolysis of the triphosphate moiety forming dUMP dUTP => dUMPMethanocaldococcus jannaschii
288Penicillin binding protein 4, Escherichia colicarboxypeptidase, enzyme Cell wall biogenesis, peptidoglycan biosynthesisendopeptidase, enzymeEscherichia coli
290RNase P protein 1, Homo sapiensMitochondrial ribonuclease P protein 1, noncatalytic subunit cleaves tRNA molecules in their 5'-ends subunit of ribonuclease P, not catalytic subunit for this function required for ribonuclease P activity tRNA methyltransferase, enzyme Homo sapiens
291Zuotin, Saccharomyces cerevisiaecomponent of a chaperone complex component of the ribosome-associated complex (RAC) that helps in folding of nascent polypeptide chainsactivator of a transcription factor activates Pdr1 transcription factor Saccharomyces cerevisiae
300Glutamine synthetase, Lactobacillus crispatusGlutamine synthetase, enzyme ATP + L-glutamate + NH3 => ADP + phosphate + L-glutamine fibronectin, laminin, collagen I binding, and plasminogen bindingLactobacillus crispatus
302aldehyde-alcohol dehydrogenase Ealdehyde alcohol dehydrogenase, alcohol dehydrogenase, acetaldehyde-CoA dehydrogenase, and pyruvate formate-lyase (PFL) deactivase activitiesbinds to ribosome and affects translation, RNA unwinding activity, RNA helicaseE. coli
303fructose-1,6-bisphosphate aldolasealdolase, cleavage of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate, in glycolysisActivation of mouse (host) macrophage protein tyrosine phosphatase-1 (SHP-1), causes macrophage disfunctionLeishmania donovani
304fructose-1,6-bisphosphate aldolasealdolase, in glycolysis and gluconeogenesis, reversible cleavage of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate.bind to and regulate insulin-dependent glucose transporter GLUT4Mus musculus (mouse)
305Fructose-bisphosphate aldolase Aaldolase, cleavage of carbon-carbon bonds, in glycolysis, gluconeogenesis, and fructose metabolism, D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate.sequesters WASP, Wiskott–Aldrich Syndrome Protein, which is involved in controlling actin dynamics, inihibits actin polymerization, only binds to active from of WASP, inhibits WA?stimulated Arp2/3?dependent actin?polymerization reactionOryctolagus cuniculus (Rabbit)
306fructose 1,6-bisphosphate aldolasefructose bisphosphate aldolase, enzyme, in glycolysis and gluconeogenesis, D-fructose 1,6-bisphosphate -> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphateadhesin, binds to receptor on host cells, binds to host Flamingo cadherin receptor (FCR)Streptococcus pneumoniae
307Fructose-bisphosphate aldolase Aaldolase, D-fructose 1,6-bisphosphate-> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, in glycolysisinteractions with zona pellucida proteins of eggHomo sapiens (human)
308alpha-ketoglutarate dehydrogenase E2alpha-ketoglutarate dehydrogenase E2, in Krebs cycle, dihydrolipoyl succinyltransferasemitochondrial DNA inheritanceTrypanosoma brucei
309Ask1part of DASH complex, which binds to microtubules and kinetochores and regulates their associationtranscriptional regulatorTuber melanosporum
310Beta-arrestin-1cytosolic regulator and scaffold of GPCR signaling, interacts with activated receptors at cell membrane, resulting in receptor endocytosis and attenuation of receptor signallingregulation of histone acetylation and gene transcription, helps recruit histone acetyltransferase p300 to specific promoters, resulting in enhanced acetylation of histone H4 and transcription of those genesHomo sapiens
311beta-arrestin-2uncouple activated seven-transmembrane receptors from heterotrimeric G proteins, mediate the endocytosis of most G-protein-coupled receptors (GPCRs)regulates transcription Homo sapiens
312Streptococcal C5a peptidaseprotease, peptidase, endopeptidase, cleaves and inactivates C5a (a component of the human complement system), helps GBS evade phagocytosisfibronectin binding, adhesinStreptococcus agalactiae, group B streptococci (GBS)
313Phosphatidylinositol-binding clathrin assembly proteinbinds clathrin in endocytosis, assembly protein helps bring clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assemblytranscription activationHomo sapiens
314COP9 signalosome complex subunit 7part of COP9 signalosome (CSN), in ubiquitin-mediated protein degradation, CSN removes the ubiquitin-like protein Nedd8 from the cullin subunit of cullin-RING E3 ligase (CRL) promote degradation of cyclin E, regulate ubiquitin-proteasome pathwayDrosophila melanogaster
315chloroplast dihydrolipoamide acetyltransferaseenzyme, pyruvate dehydrogenase complex subunit in chloroplast, dihydrolipoamide acetyltransferase (DLA2), helps provide acetyl-CoA for fatty acid synthesisRNA bindingChlamydomonas reinhardtii (unicellular green alga)(Chlamydomonas smithii)
316DPP4, dipeptidyl peptidase 4serine exopeptidase, dipeptidyl peptidase, regulates several physiological processes by cleaving peptides in the blood, i.e. chemokines, growth factors, neuropeptides, removes N-terminal dipeptides from proteins with unsubstituted N-termini as long as the second residue is prolineglycoprotein receptor, involved in T-cell activation, binds ADA, CAV1, IGF2R, and PTPRCHomo sapiens (human)
317DPP10, dipeptidyl peptidase 10enzyme, dipeptidyl peptidase activity with Gly-Pro-MCA (glycyl-L-proline 4-methylcoumaryl-7-amide) as a substrateancillary subunit of Kv4 channels, bind to pore-forming subunits of voltage-gated K+ channels, causes negative shifts in voltage dependence of channel activation and steady state inactivationDrosophila melanogaster
318EF-1-alphaelongation factorregulate cell motility by assembling actin filamentDictyostelium discoideium (slime mold)
319Eukaryotic elongation factor 1 A-1translation elongation factorbinds and severs microtubulesHomo sapiens (human)
320elongation factor 1-alphatranslation elongation factor, the rate and fidelity of protein translationbinds to and activates Src homology 2 domain containing tyrosine phosphatase-1 (SHP-1) in host macrophages, inhibits activity of infected macrophagesLeishmania donovani
321Elongation factor 1-alpha 1translation elongation factorbinds and severs microtubulesOryctolagus cuniculus (rabbit)
322elongation factor 1 alphatranslation elongation factorbinds and severs microtubulesXenopus laevis (African clawed frog)
323translation elongation factor Tutranslation elongation factor TuMucin (MUC7)-binding proteinStreptococcus gordonii
324Eukaryotic translation initiation factor 3 subunit Apart of eIF3 13-subunit complex that organizes initiation factor and ribosome interactions required for productive translation, protein scaffold for formation of initiation complexes, binds to proteins of small ribosomal subunitbinds to 5' untranslated regions of specific mRNA for translational activation, subunits a, b, d, g, binding site on mRNA for c-Jun is required for efficient translation of c-JUNhuman, homo sapiens
325Eukaryotic translation initiation factor 3 subunit Bpart of eIF3 13-subunit complex that organizes initiation factor and ribosome interactions required for productive translation, protein scaffold for formation of initiation complexes, binds to proteins of small ribosomal subunitbinds to 5' untranslated regions of specific mRNA for translational activation, subunits a, b, d, g, binding site on mRNA for c-Jun is required for efficient translation of c-JUNhuman, homo sapiens
326Eukaryotic translation initiation factor 3 subunit Dpart of eIF3 13-subunit complex that organizes initiation factor and ribosome interactions required for productive translation, protein scaffold for formation of initiation complexes, binds to proteins of small ribosomal subunitbinds to 5' untranslated regions of specific mRNA for translational activation, subunits a, b, d, g, binding site on mRNA for c-Jun is required for efficient translation of c-JUNhuman, homo sapiens
327Eukaryotic translation initiation factor 3 subunit Gpart of eIF3 13-subunit complex that organizes initiation factor and ribosome interactions required for productive translation, protein scaffold for formation of initiation complexes, binds to proteins of small ribosomal subunitbinds to 5' untranslated regions of specific mRNA for translational activation, subunits a, b, d, g, binding site on mRNA for c-Jun is required for efficient translation of c-JUNhuman, homo sapiens
328elongation factor 2translation elongation factorbinding partner for Akt2 signalling moleculeHomo sapiens (human)
329endopeptidase Oendopeptidase, metalloendopeptidaseplasminogen binding protein, fibronectin binding proteinStreptococcus pneumoniae
330enolase, 2-phospho-D-glycerate hydrolaseenolase, catalyze the conversion of 2-phosphoglycerate (2-PGA) to phosphoenolpyruvate (PEP), in glycosisplasminogen and fibronectin bindingMycoplasma synoviae
331enolase, 2-phospho-D-glycerate hydro-lyaseenolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase, 2-phospho-D-glycerate -> phosphoenolpyruvate, in glycolysisplasminogen binding, also maybe EBP binding, also maybe adhesin Plasmodium falciparum
332enolase, 2-phospho-D-glycerate hydro-lyaseenolase, in glycolysis, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydrataseplasminogen bindingStreptococcus canis, group G Streptococci
333enolase, 2-phospho-D-glycerate hydro-lyaseenolase, enzyme, in glycolysis, 2-phosphoglycerate => phosphoenolpyruvatebinds Cytokeratin 8 (CK8) of host cellsStreptococcus gallolyticus
334enolaseenolaseantiphagocytic activity of host (insect), affects host immune system, host immune suppressionSteinernema glaseri (nematode)
335Methylglutaconyl-CoA hydratase3-methylglutaconyl-CoA hydratase that catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) in leucine catabolismRNA bindingHomo sapiens (human)
336Epidermal growth factor receptor substrate 15binds clathrin, clathrin adapter in post-Golgi trafficking, also role in assembly of clathrin-coated pitstranscription activationHomo sapiens
337Fructose-1,6-bisphosphatasefructose-1,6-bisphosphatase 1, enzyme in gluconeogenesis, D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + phosphatebinds to HIF (hypoxia inducible factor) protein and inhibits nuclear HIF actionHomo sapiens (human)
338Glyceraldehyde-3-phosphate dehydrogenaseglyceraldehyde 3-phosphate dehydrogenase, enzyme, D-glyceraldehyde 3-phosphate + phosphate + NAD+ => 3-phospho-D-glyceroyl phosphate + NADHsingle stranded DNA binding (SSB), effects on the DNA-polymerase-alpha- primase complexBos taurus
339glyceraldehyde-3-phosphate dehydrogenaseenzyme, glyceraldehyde 3-phosphate dehydrogenase, D-glyceraldehyde 3-phosphate (G3P) -> 3-phospho-D-glyceroyl phosphate, in glycolysistransferrin receptor, iron uptakeCricetulus griseus, hamster (Chinese hamster, CHO cells)
340glyceraldehyde-3-phosphate dehydrogenaseGAPDH, glyceraldehyde-3-phosphate dehydrogenase, in glycolysis, D-glyceraldehyde 3-phosphate + phosphate + NAD+ -> 3-phospho-D-glyceroyl phosphate + NADHbinding alternative complement pathway protein C3, inhibit complement cascade, evade host immunityHaemonchus contortus (Barber pole worm)
341glyceraldehyde-3-phosphate dehydrogenaseglyceraldehyde-3-phosphate dehydrogenase, enzyme in glycolysis, oxidative phosphorylation of G3P (glyceraldehyde 3-phosphate) to 1, 3-bisphosphoglycerate in the presence ofNADH/NADPH and inorganic phosphatemucin bindingLactobacillus acidophilus
344glyceraldehyde-3-phosphate dehydrogenaseglyceraldehyde 3-phosphate dehydrogenase, in glycolysis, D-glyceraldehyde 3-phosphate (G3P) <-> 3-phospho-D-glyceroyl phosphatebind mRNA AU-rich element (ARE), regulation of cyclo-oxygenase-2 (COX-2) expressio, binding to COX-2 mRNAMus musculus (mouse)
345Glyceraldehyde-3-phosphate dehydrogenaseGlyceraldehyde-3-phosphate dehydrogenase, GAPDH, in glycolysis, conversion of glyceraldehyde 3-phosphate into glycerate 1,3-bisphosphateheme binding protein, required for the insertion of cellular heme into inducible nitric oxide synthaseOryctolagus cuniculus, rabbit
346glyceraldehyde 3-phosphage dehydrogenaseGAPDH, in glycolysis, catalyzing the phosphorylation of glyceraldehyde-3-phosphate to D-glycerate 1,3-bisphosphateadhesinTalaromyces marneffei (Penicillium marneffei)
347Glyceraldehyde-3-phosphate dehydrogenaseGAPDH, converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate, enzyme in glycolysis, glyceraldehyde 3-phosphate + phosphate + NAD+ => 3-phospho-D-glyceroyl phosphate + NADHbinds to Siah1, involved in apoptosisRattus norvegicus (rat)
348Glyceraldehyde-3-phosphate dehydrogenase 3GAPDH, glyceraldehyde 3-phosphate dehydrogenasebinds to Sir2, regulates gene silencing by influencing Sir2’s association with chromatin, especially near telomeresSaccharomyces cerevisiae
349glutathione S-transferase M3glutathione S-transferasebinds to rhZP4, in head of sperm, interactions with zona pellucida proteins of eggHomo sapiens (human)
350glutathione S-transferaseglutathione S-transferase, detoxify electrophilic compoundsbinds ZP3 protein component of zona pellucida, serves as a gamete recognition molecule, binds specifically to zona pellucida (of egg) during the first phase of sperm–oocyte interactionsCapra hircus (goat)
352glycerol 3-phosphate dehydrogenaseglycerol 3-phosphate dehydrogenase, functions in glycerol accumulationplasminogen bindingCandida albicans
353glycyl-tRNA synthetaseglycyl-tRNA synthetase, catalyze the formation of glycyl-tRNAGly as a substrate for ribosomal protein synthesis, P41250 (SYG_HUMAN), ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly) AND P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O => GTP + GMPbinds to NEDD8, E1, and E2 (Ubc12) in neddylation pathway, binds the APPBP1 subunit of E1 and captures and protects (like a chaperone) activated E2 (NEDD8-conjugated Ubc12) before the activated E2 reaches a downstream targetHomo sapiens (human)
354glycyl tRNA synthetaseglycyl tRNA synthetase, catalyzes attachment of glycine to its cognate tRNA, ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly) AND P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O => GTP + GMP****NEOMORPHIC MOONLIGHTING PROTEIN***, mutant forms have protein binding activity, bind to neuropilin 1 (Nrp1) recpeptor, directly antagonizes binding of the ligand VEGF (vascular endothelial growth factor) to Nrp1, which is an essential signaling pathway in survival of motor neuronMus musculus (mouse)
355hydroxyacyl-CoA dehydrogenase, subunit betaenzyme, 3-ketoacyl-CoA thiolase activityRNA binding, binds 3'UTR of REN mRNA which results in regulation of renin expression, destabilizes REN mRNAHomo sapiens (human)
356phosphopantothenoylcysteine decarboxylasephosphopantothenoylcysteine decarboxylase, decarboxylation of phosphopahtothenoyl-L-cysteine, in CoA biosynthesis, PPCDCinhibitor of serine/threoinine phosphatase Pzh1Schizosaccharomyces pombe
357Protein deglycase 1chaperoneglyoxylase III, enzyme, catalyses the conversion of methylglyoxal (MG) to D-lactateEscherichia coli
358hexokinase-1hexokinase, enzyme, in glycolysis, ATP + D-hexose => D-hexose 6-phosphate + ADPreceptor for bacterial NAG (N-acetylglucosamine), activates inflammasome responseMus musculus
359hexokinase 1hexokinase, ATP + D-hexose => ADP + D-hexose 6-phosphatebinds to vacuolar H+-ATPase B1 (VHA-B1) and the 19S regulatory particle of proteasome subunit (RPT5B) to modulate transcription of specific target genesArabidopsis thaliana
360high-affinity glucose transporter 1sugar transporter, glucose transportercomplement inhibitor, binds complement regulator FH, binds complement regulator C4BP, protects cells from host complement cascade, complement evasion resulting in reduced formation of the potentially lytic terminal complex (TCC)Candida albicans
361LYS20homocitrate synthase, enzyme, lysine biosynthetic pathwayDNA damage repair, helps in INO80 accumulation at DNA breaks to aid in histone evictionSaccharomyces cerevisiae
362Hsp60chaperoninbinds DNA, bind the template strand of active mtDNA ori sequences in vitro, involved in structure and transmission of mitochondrial DNA nucleoids to daughter cellsSaccharomyces cerevisiae
364Inositol-pentakisphosphate 2-kinasekinase, ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate => ADP + 1D-myo-inositol hexakisphosphate.scaffold, binds protein kinase CK2, TCOF1, and upstream-binding-factor (UBF)Homo sapiens (human)
365lactate dehydrogenase isozyme Menzyme, lactate + NAD+ -> pyruvate + NADHRNA binding protein, post-transcriptional regulation of gene expression, AU-rich element (ARE, binding to these kinds of elements can be involved in affecting RNA stability) binding protein (AUBP), role may also involve binding to AUF1 protein, binds the 3 -UTR of GM-CSF RNAMus musculus (mouse)
367nuclear cytoplasmic O-GlcNAcase and acetyltransferaseO-GlcNase, which removes regulatory O-GlcNAc modifications on proteinshistone acetyltransferase (HAT), add acetyl groups to histonesmouse
368outer dense fiber protein 2component of sperm tail outer dense fibersinteractions with zona pellucida proteins of eggHomo sapiens (human)
369phosphoadenosine-phosphosulfate reductasephosphoadenosine-phosphosulfate reductase (thioredoxin), enzyme in sulfur assimilation, conversion of activated sulfate (PAPS) to sulfite, adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide <-> 3'-phosphoadenylyl sulfate + thioredoxintranscription factorTuber melanosporum (Perigord black truffle, filamentous mycorrhizal ascomycetous fungus)
370mitochondrial 2-cysteine peroxiredoxinperoxidase activity, detoxification of reactive oxygen species (ROS), removal of peroxide, use redox active cysteine residue (peroxidatic Cys) to reduce substrates like H2O2chaperone and activators of signal transduction cascades, prevents thermal aggregation of citrate synthase in vitro, lack of expression makes promastigoes more sensitive to temperature in the mammalian host (37°C)Leishmania infantum
372peroxiredoxin 5peroxiredoxinsperm plasma membrane protein interacting with zona pellucida proteinsSus scrofa (pig)
373Alkyl Hydroperoxide Reductase Cperoxiredoxin, hydroxyperoxidase activityheme binding proteinStreptococcus agalactiae, group B Streptococcus
374phosphofructokinase 1phosphofructokinase, enzyme in glycolysis, first committed step of glycolysis, by phosphorylating F6P into fructose-1,6-bisphosphate (F1,6P), ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphatebinds TEADs proteins and promotes their interaction with YAP/TAX transcription factorsHomo sapiens (human)
375phosphoglycerate kinase 1phosphoglycerate kinase, enzyme, reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglyceratebinds mRNA, regulates expression of urokinase receptor, "Overexpression in H157 lung squamous carcinoma cells reduced cell surface uPAR expression as well as uPAR-mediated cellular functions at the post-transcriptional level."Homo sapiens (human)
376phosphoglycerate kinaseenzyme, phosphoglycerate kinase, in glycolysis, ATP + 3-phospho-D-glycerate -> ADP + 3-phospho-D-glyceroyl phosphatebinding to actin filament in insect vector (Circulifer haemotoceps, leafhopper) during invasionSpiroplasma citri, a plant bacterial pathogen transmitted by insects
377glutathione peroxidase 4phospholipid hydroperoxide glutathione peroxidase, 2 glutathione + a hydroperoxy-fatty-acyl-[lipid] -> glutathione disulfide + a hydroxy-fatty-acyl-[lipid]interactions with zona pellucida proteins of eggHomo sapiens (human)
378pinintranscriptional activatorbinds RNA, involved in splicing of pre-mRNAsHomo sapiens (human)
379pyruvate kinase 3, isoform 2pyruvate kinase, ATP + pyruvate -> ADP + phosphoenolpyruvate, in glycolysisinteractions with zona pellucida proteins of eggHomo sapiens (human)
380pyruvate decarboxylasepyruvate decarboxylase, 2-oxo acid -> an aldehyde + CO2transcriptional regulator but might not bind DNA directly (possibly by sequestering Rag3 in the cytoplasm), inhibits transcription from PDC1 and PDC5 promotersKluyveromyces lactis
381pyruvate dehydrogenase E2 subunitpyruvate dehydrogenase E2 subunit, dihydrolipoamide acetyltransferaseDNA binding, transcription regulationBacillus thuringiensis
382pyruvate kinase 1pyruvate kinase, ATP + pyruvate <=> ADP + phosphoenolpyruvate.histone kinase, phosphorylates H3T11, protein kinase, part of SESAME complexSaccharomyces cerevisiae
383pyruvate kinase isozyme type M2pyruvate kinase, enzyme, glycolysis, ATP + pyruvate <=> ADP + phosphoenolpyruvateregulates transcription, binds to Oct-4 proteinHomo sapiens (human)
385Leucyl aminopeptidase leucine aminopeptidase (LAP) binds to heparinMycoplasma hyopneumoniae
387DNA-directed RNA polymerase beta subunitbeta subunit of DNA-directed RNA polymeraseMuc7 binding proteinStreptococcus gordonii
388Regulatory particle triple-A ATPase subunit 5bpart of the regulatory ATPase complex of the 26S proteasome, confers substrate specificity and need for ATP to the proteaseomebinds to hexokinase 1 and VHA B1 to modulate transcription of specific target genesArabidopsis thaliana
390succinate dehydrogenase subunit 3subunit of succinate dehydrogenase in the respiratory chain, electron transport in respiratory complex IIpart of TIM22 complex (carrier translocase, mitochondrial inner membrane translocase) in mitochondria, helps in biogenesis and assembly of membrane-integral subunits of TIM22 complexSaccharomyces cerevisiae
391superoxide dismutasesuperoxide dismutase, catalysis of superoxide (O2-) to hydrogen peroxide (H2O2), remove reactive oxygen species, 2 superoxide -> oxygen and H2O2binds DNA, transcription factor in response to H2O2, a reactive oxygen species (ROS), regulates expression of genes involved in oxidative resistance and DNA damage repair, ROS treatment increases Sod1 binding to the promoters of RNR3 and GRE2Saccharomyces cerevisiae
392Threonine-tRNA ligasethreonyl aminoacyl-tRNA synthetase, attaches threonine to tRNA, early step in protein synthesis, ATP + L-threonine + tRNA(Thr) -> AMP + diphosphate + L-threonyl-tRNA(Thr)promotes vascular development, demostrated this is separate from role in protein synthesisDanio rerio (Zebrafish) (Brachydanio rerio)
393Threonine-tRNA ligasethreonyl aminoacyl-tRNA synthetase, attaches threonine to tRNA, early step in protein synthesis, ATP + L-threonine + tRNA(Thr) -> AMP + diphosphate + L-threonyl-tRNA(Thr)promotes vascular development, demostrated this is separate from role in protein synthesisHomo sapiens (human)
394 triose-phosphate isomerasetriosephosphate isomerase, D-glyceraldehyde 3-phosphate <-> dihydroxyacetone phosphate, in glycolysis and gluconeogenesisinteract with rhZP3 and rhZP4, interactions with zona pellucida proteins of eggHomo sapiens (human)
395VDAC-2voltage-dependent anion channel 2 (VDAC2), transports adenine nucleotides, Ca2+ and other metabolites, voltage-dependentbinds to rhZP2 or rhZP3, zona pellucida proteins of eggHomo sapiens, human
396VHA-B1subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase functions in acidifying several intracellular compartments in eukaryotic cellsbinds to hexokinase 1 and the 19S regulatory particle of proteasome subunit (RPT5B) to modulate transcription of specific target genesArabidopsis thaliana
397VPS22component of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesiclesbind bicoid mRNA to cause localization to anterior of eggDrosophila melanogaster
398ESCRT-II complex subunit VPS25component of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesiclesbind bicoid mRNA to cause localization to anterior of eggDrosophila melanogaster
399ESCRT-II complex subunit VPS36component of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesiclesbind bicoid mRNA to cause localization to anterior of egg, binding directly and specifically to stem-loop V of the bicoid 39 UTRDrosophila melanogaster